Carcinogenesis is accompanied by widespread DNA methylation changes within the cell.
These changes are characterized by a globally hypomethylated genome with focal …

DNA methylation is an epigenetic mechanism regulating gene expression. Changes in DNA
methylation were suggested to be useful biomarkers for diagnosis, and for the determination …

Abstract Changes in DNA methylation in cancer have been heralded as promising targets
for the development of powerful diagnostic, prognostic, and predictive biomarkers. Despite …

Colorectal cancer (CRC) is still a leading cause of cancer death worldwide. Less than half of
cases are diagnosed when the cancer is locally advanced. CRC is a heterogenous disease …

Stimulator of interferon genes (STING) has been shown to be critical for controlling antiviral
responses as well as anti-tumor adaptive immunity, but little is known regarding its …

DNA methylation provides a pivotal layer of epigenetic regulation in eukaryotes that has
significant involvement for numerous biological processes in health and disease. The …

The innate immunoregulator STING stimulates cytokine production in response to the
presence of cytosolic DNA, which can arise following DNA damage. Extrinsic STING …

Biomarkers are naturally-occurring characteristics by which a particular pathological process
or disease can be identified or monitored. They can reflect past environmental exposures …

Since genetic and epigenetic alterations influence the development of colorectal cancer
(CRC), huge potential lies in the use of DNA methylation as biomarkers to improve the …

Background Colorectal cancer (CRC) screening can effectively reduce disease-related
mortality by detecting CRC at earlier stages. We have previously demonstrated that the …