The past few years have seen an explosion of interest in the epigenetics of cancer. This has
been a consequence of both the exciting coalescence of the chromatin and DNA …

Objective To provide an introduction to the concept of DNA methylation and its function in
normal cells, and to explain the possible mechanisms as to how abnormalities in this …

We have studied the feasibility of detecting tumor-associated aberrant p16 methylation in the
circulation of patients with hepatocellular carcinoma (HCC). We extracted DNA from the …

DAP kinase is a new type of calcium/calmodulin-dependent enzyme that phosphorylates
serine/threonine residues on proteins. Its structure contains ankyrin repeats and the …

Esophageal adenocarcinoma (EAC) is thought to develop through a multistage process in
which Barrett's metaplasia progresses through low-and high-grade dysplasia to invasive …

This well-organized and clearly written text has a unique focus on methods of identifying the
joint effects of genes and environment on disease patterns. It follows the natural sequence of …

Carcinoma of the lung is the most common cause of cancer death worldwide. The estimated
5-year survival ranges from 6–16%, depending on the cell type. The best opportunity for …

DNA methylation and histone modification promote changes in chromatin structure that may
affect gene expression in a heritable manner without directly altering the genome. As such …

Compiling significant advances from more than a decade of research, this text presents
breakthroughs in the prevention, treatment, and control of cancer-exploring the origin …

DNA methylation is an epigenetic mechanism that regulates chromosomal stability and gene
expression. Abnormal DNA methylation patterns have been observed in many types of …