Unfolded stress response (UPR) is a conserved cellular pathway involved in protein quality
control to maintain homeostasis under different conditions and disease states characterized …

Bipolar disorder (BD) has been associated with immune changes, and yet their underlying
mechanisms are still not fully understood. Here, we review the current state of the field …

Significance: Our current knowledge of the pathophysiology and molecular mechanisms
causing psychiatric disorders is modest, but genetic susceptibility and environmental factors …

Nuclear factor erythroid 2-related factor 2 (Nrf2) is a transcription factor encoded by NFE2L2.
Under oxidative stress, Nrf2 does not undergo its normal cytoplasmic degradation but …

Increasing evidence indicates lithium (Li+) efficacy in neuropsychiatry, pointing to
overlapping mechanisms that occur within distinct neuronal populations. In fact, the same …

Here an overview is provided on therapeutic/neuroprotective effects of Lithium (Li+) in
neurodegenerative and psychiatric disorders focusing on the conspicuous action of Li+ …

Bipolar disorder (BD) is characterized by mood changes, including recurrent manic,
hypomanic, and depressive episodes, which may involve mixed symptoms. Despite the …

Bipolar disorders (BDs) are severe and common psychiatric disorders. BD pathogenesis,
clinical manifestations and relapses are associated with numerous circadian rhythm …

Peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1 alpha) is a
protein that regulates metabolism and inflammation by activating nuclear receptors …

Nitro-oxidative stress and lowered antioxidant defences play a key role in neuropsychiatric
disorders such as major depression, bipolar disorder and schizophrenia. The first part of this …