Overcoming challenges and dogmas to understand the functions of pseudogenes

SW Cheetham, GJ Faulkner, ME Dinger - Nature Reviews Genetics, 2020 - nature.com
Pseudogenes are defined as regions of the genome that contain defective copies of genes.
They exist across almost all forms of life, and in mammalian genomes are annotated in …

The genetics and epigenetics of 22q11. 2 deletion syndrome

Q Du, MT de la Morena, NSC van Oers - Frontiers in Genetics, 2020 - frontiersin.org
Chromosome 22q11. 2 deletion syndrome (22q11. 2del) is a complex, multi-organ disorder
noted for its varying severity and penetrance among those affected. The clinical problems …

MicroRNAs, long noncoding RNAs, and circular RNAs: potential tumor biomarkers and targets for colorectal cancer

S Yang, Z Sun, Q Zhou, W Wang, G Wang… - Cancer management …, 2018 - Taylor & Francis
Noncoding RNAs (ncRNAs) can be divided into microRNAs (miRNAs), long noncoding
RNAs (lncRNAs), circular RNAs (circRNAs), pRNAs, and tRNAs. Traditionally, miRNAs exert …

Pseudogenes as functionally significant elements of the genome

TF Kovalenko, LI Patrushev - Biochemistry (Moscow), 2018 - Springer
Pseudogene is a gene copy that has lost its original function. For a long time, pseudogenes
have been considered as “junk DNA” that inevitably arises as a result of ongoing …

LncRNA EBLN3P promotes the progression of osteosarcoma through modifying the miR-224-5p/Rab10 signaling axis

S Dai, N Li, M Zhou, Y Yuan, D Yue, T Li, X Zhang - Scientific Reports, 2021 - nature.com
The treatment of patients with advanced-stage osteosarcoma represents a major challenge,
with very few treatments currently approved. Although accumulating evidence has …

The world of pseudogenes: new diagnostic and therapeutic targets in cancers or still mystery molecules?

M Stasiak, T Kolenda, J Kozłowska-Masłoń… - Life, 2021 - mdpi.com
Pseudogenes were once considered as “junk DNA”, due to loss of their functions as a result
of the accumulation of mutations, such as frameshift and presence of premature stop-codons …

Identification and expression analysis of long noncoding RNAs in fat-tail of sheep breeds

MR Bakhtiarizadeh, SA Salami - G3: Genes, Genomes …, 2019 - academic.oup.com
Emerging evidence suggests that long non-coding RNAs (lncRNAs) participate in the
regulation of a diverse range of biological processes. However, most studies have been …

HAR1: An Insight Into lncRNA Genetic Evolution

E Waters, P Pucci, M Hirst, S Chapman, Y Wang… - …, 2021 - Taylor & Francis
Long noncoding RNAs (lncRNAs) have a wide range of functions in health and disease, but
many remain uncharacterized because of their complex expression patterns and structures …

A family of long intergenic non-coding RNA genes in human chromosomal region 22q11. 2 carry a DNA translocation breakpoint/AT-rich sequence

N Delihas - PLoS One, 2018 - journals.plos.org
FAM230C, a long intergenic non-coding RNA (lincRNA) gene in human chromosome 13
(chr13) is a member of lincRNA genes termed family with sequence similarity 230. An …

[HTML][HTML] Long noncoding RNAs are associated with metabolic and cellular processes in the jejunum mucosa of pre-weaning calves in response to different diets

R Weikard, F Hadlich, HM Hammon, D Frieten… - Oncotarget, 2018 - ncbi.nlm.nih.gov
Long noncoding RNAs are associated with metabolic and cellular processes in the jejunum
mucosa of pre-weaning calves in response to different diets - PMC Back to Top Skip to main …