The gut microbial metabolite trimethylamine N-oxide and cardiovascular diseases

J Zhen, Z Zhou, M He, HX Han, EH Lv… - Frontiers in …, 2023 - frontiersin.org
Morbidity and mortality of cardiovascular diseases (CVDs) are exceedingly high worldwide.
Researchers have found that the occurrence and development of CVDs are closely related …

Gut microbiota-derived TMAO: a causal factor promoting atherosclerotic cardiovascular disease?

M Canyelles, C Borràs, N Rotllan, M Tondo… - International journal of …, 2023 - mdpi.com
Trimethylamine-N-oxide (TMAO) is the main diet-induced metabolite produced by the gut
microbiota, and it is mainly eliminated through renal excretion. TMAO has been correlated …

[HTML][HTML] Gut microbiota–derived metabolite trimethylamine-N-oxide and multiple health outcomes: an umbrella review and updated meta-analysis

D Li, Y Lu, S Yuan, X Cai, Y He, J Chen, Q Wu… - The American journal of …, 2022 - Elsevier
ABSTRACT Background Trimethylamine-N-oxide (TMAO) is a gut microbiota–derived
metabolite produced from dietary nutrients. Many studies have discovered that circulating …

Gut microbiota-derived metabolites and cardiovascular disease risk: a systematic review of prospective cohort studies

R Sanchez-Gimenez, W Ahmed-Khodja, Y Molina… - Nutrients, 2022 - mdpi.com
Gut microbiota-derived metabolites have recently attracted considerable attention due to
their role in host-microbial crosstalk and their link with cardiovascular health. The MEDLINE …

Nephroprotective plants: a review on the use in pre-renal and post-renal diseases

MA Tienda-Vázquez, ZP Morreeuw… - Plants, 2022 - mdpi.com
Kidney diseases are expected to become the fifth leading cause of death by 2040. Several
physiological failures classified as pre-, intra-, and post-renal factors induce kidney damage …

The Influence of Animal- or Plant-Based Diets on Blood and Urine Trimethylamine-N-Oxide (TMAO) Levels in Humans

M Lombardo, G Aulisa, D Marcon, G Rizzo - Current Nutrition Reports, 2022 - Springer
Abstract Purpose of Review The aim of the review was to evaluate which diets are
associated with higher TMAO levels. Recent Findings Several studies have shown that …

The role and mechanism of gut microbiota-derived short-chain fatty in the prevention and treatment of diabetic kidney disease

P Tao, J Ji, Q Wang, M Cui, M Cao, Y Xu - Frontiers in Immunology, 2022 - frontiersin.org
Diabetic kidney disease (DKD), an emerging global health issue, is one of the most severe
microvascular complications derived from diabetes and a primary pathology contributing to …

Gut microbiota-derived trimethylamine N-oxide is associated with the risk of all-cause and cardiovascular mortality in patients with chronic kidney disease: a …

Y Li, H Lu, J Guo, M Zhang, H Zheng, Y Liu… - Annals of …, 2023 - Taylor & Francis
Abstract Background Trimethylamine N-oxide (TMAO) derived from gut microbiota causes
kidney-heart damage in chronic kidney disease (CKD) patients. However, it is controversial …

[HTML][HTML] Intestinal flora: a potential new regulator of cardiovascular disease

Y Zou, X Song, N Liu, W Sun, B Liu - Aging and Disease, 2022 - ncbi.nlm.nih.gov
Although substantial progress has been made in reducing the burden of the disease by
preventing the risk factors of cardiovascular disease (CVD), potential risk factors still exist …

Circulating metabolites associate with and improve the prediction of all-cause mortality in type 2 diabetes

MG Scarale, M Mastroianno, C Prehn, M Copetti… - Diabetes, 2022 - Am Diabetes Assoc
Death rate is increased in type 2 diabetes. Unraveling biomarkers of novel pathogenic
pathways capable to identify high-risk patients is instrumental to tackle this burden. We …