Adverse childhood experiences (ACEs) may be referred to by other terms (eg, early life
adversity or stress and childhood trauma) and have a lifelong impact on mental and physical …

Sažetak Estrogens have long been known as important regulators of the female
reproductive functions; however, our understanding of the role estrogens play in the human …

Smart drug delivery systems (DDSs) have attracted the attention of many scientists, as
carriers that can be stimulated by changes in environmental parameters such as …

Regulatory T (Treg) cells are a developmentally and functionally distinct T cell
subpopulation that is engaged in sustaining immunological self-tolerance and homeostasis …

Epigenetic mechanisms are implicated in gene regulation and the development of different
diseases. The epigenome differs between cell types and has until now only been …

The transcription factor Foxp3 is essential for the development of regulatory T (Treg) cells,
yet its expression is insufficient for establishing the Treg cell lineage. Here we showed that …

Micronuclei (MN) are extra-nuclear bodies that contain damaged chromosome fragments
and/or whole chromosomes that were not incorporated into the nucleus after cell division …

Programmed cell death protein 1 (PD-1), expressed on tumor-infiltrating T cells, is a T cell
exhaustion marker. The mechanisms underlying PD-1 upregulation in CD4 T cells remain …

Epigenetic modifications of chromatin play a critical role in regulating the fidelity of the
genetic code and in controlling the translation of genetic information into the protein …

Context Several small studies have suggested that the gut microbiome might influence
osteoporosis, but there is little evidence from human metabolomics studies to explain this …