Members of the COE family of transcription factors are required for central nervous system
(CNS) development. However, the function of COE in the post-embryonic CNS remains …

Abstract Background Hypermethylation of promoter CpG islands with associated loss of
gene expression, and hypomethylation of CpG-rich repetitive elements that may destabilize …

Abstract Purpose: Aberrant methylation of CpG islands can be a good molecular marker for
identifying genes inactivated in cancer. We found the proapoptotic gene HRK to be a target …

Human cancer genome and epigenome projects aim to identify new cancer genes and
targets for therapy that have been overlooked by conventional approaches. Here we …

Genetic and epigenetic mechanisms contribute to the development of human tumors.
However, the conventional analysis of neoplasias has preferentially focused on only one of …

Gene amplification is an important mechanism of oncogene activation in various human
cancers, including ovarian carcinomas (OvCas). We used restriction landmark genomic …

Epigenetics refers to heritable phenotypic alterations in the absence of DNA sequence
changes, and DNA methylation is one of the extensively studied epigenetic alterations. DNA …

Suppressor of cytokine signaling 1 (SOCS1) is considered as a tumor suppressor protein in
hepatocellular carcinoma (HCC), but the underlying mechanisms remain unclear …

In a genome-wide screen for putative tumor suppressor genes, the EBF3 locus on the
human chromosome 10q26. 3 was found to be deleted or methylated in 73% of the …

Both genetic and epigenetic mechanisms contribute to meningioma development by altering
gene expression and protein function. To determine the relative contribution of each …