Every day, human renal tubules process 140 l of glomerular filtrate into 1 l of urine. They
accomplish this by the coordinated function of distinct cell types occupying specific positions …

Autosomal dominant polycystic kidney disease (ADPKD) is a genetic disease characterized
by the formation of renal cysts. This disease can be caused by mutations in two genes …

Polycystic kidney disease (PKD) describes a heterogeneous collection of disorders that
differ significantly with respect to their etiology and clinical presentation. They share …

Abstract Polycystin-1 (PC-1), the PKD1 gene product, is a large receptor whose expression
in renal epithelial cells results in resistance to apoptosis and tubulogenesis, a model …

Bacteria have long been known to secrete enzymes that degrade cellulose and chitin. The
degradation of these two polymers predominantly involves two enzyme families that work …

The PKD1 or PKD2 genes encode polycystins (PC) 1 and 2, which are associated with
polycystic kidney disease. Previously we demonstrated that PC2 interacts with the inositol 1 …

The cerebrospinal fluid (CSF) is circulating around the entire central nervous system (CNS).
The main function of the CSF has been thought to insure the global homeostasis of the CNS …

The oocyte plays a key role in follicular development. At all stages of follicular development,
oocytes interact with surrounding granulosa cells and promote their differentiation into the …

目的: 观察角质细胞生长因子(KGF) 在体外对常染色体显性遗传型多囊肾病(ADPKD)
囊肿衬里上皮细胞的促增殖探讨其可能的作用机制. 方法: 外源性给予不同浓度的KGF (0 …

The Pkd2 gene encodes an integral protein (~ 130 kDa), named polycystin-2 (PC-2). PC-2 is
mainly involved in autosomal dominant polycystic kidney disease. Recently, polycystin …