Critically ill pediatric patients often require complex medical procedures as well as invasive
testing and monitoring which tend to be painful and anxiety-provoking, necessitating the …

OBJECTIVE: To develop comprehensive clinical practice guidelines for critically ill infants
and children, with specific attention to seven domains of care including pain …

We aim to develop evidence-based recommendations for intensivists caring for children
admitted to intensive care units and requiring analgesia and sedation. A panel of national …

Objectives Health economics analysis plans (HEAPs) currently lack consistency, with
uncertainty surrounding appropriate content. We aimed to develop a list of essential items …

Over the past two decades, pediatric intensive care research networks have been formed
across North America, Europe, Asia, and Australia/New Zealand. The UK Paediatric Critical …

Objective: Children in PICUs normally require analgesics and sedatives to maintain comfort,
safety, and cooperation with interventions. α 2-agonists (clonidine and dexmedetomidine) …

Background This systematic review and meta-analysis investigates the efficacy and safety of
clonidine as a sedative in critically ill patients requiring invasive mechanical ventilation …

Cost‐effectiveness analyses (CEA) conducted alongside randomised trials provide key
evidence for informing healthcare decision making, but missing data pose substantive …

In the last decades, the advancement of knowledge in analgesia and sedation for critically ill
pediatric patients has been conspicuous and relevant. Many recommendations have …

Inadequate pain and/or stress management in preterm‐and term‐born infants has been
associated with increased morbidity and even mortality. However, exposure to …