Hepatocellular cancer is the fifth most frequent cancer in men and the eighth in women
worldwide. Established risk factors are chronic hepatitis B and C infection, chronic heavy …

Methionine adenosyltransferase 2A (MAT2A) is a rate-limiting enzyme in the methionine
cycle that primarily catalyzes the synthesis of S-adenosylmethionine (SAM) from methionine …

Hypoxia is often found in solid tumors and is associated with tumor progression and poor
clinical outcomes. The exact mechanisms related to hypoxia‐induced invasion and …

Familial inheritance of drug abuse is composed of both genetic and environmental factors.
Additionally, epigenetic transgenerational inheritance may provide a means by which …

The transsulfuration pathway converts homocysteine to cysteine and represents the
metabolic link between antioxidant and methylation metabolism. The first and committing …

Background Alcohol is classified as a Group 1 carcinogen by the International Agency for
Research on Cancer because it induces hepatocellular carcinoma (among other cancers) in …

Downregulation of liver-specific MAT1A gene, encoding S-adenosylmethionine (SAM)
synthesizing isozymes MATI/III, and upregulation of widely expressed MAT2A, encoding …

Abstract Hypoxia-inducible factor 1 (HIF-1) emerges as a crucial player in tumor
progression. However, its role in hepatocellular carcinoma (HCC), especially its relation with …

GR15 is a short molecule or peptide composed of aliphatic amino acids and possesses to
have antioxidant properties. The GR15, 1 GGGAFSGKDPTKVDR 15 was identified from the …

Alcoholic liver disease (ALD) is typically associated with folate deficiency, which is the result
of reduced dietary folate intake, intestinal malabsorption, reduced liver uptake and storage …