Several researchers have analyzed the alterations of the methionine cycle associated with
liver disease to clarify the pathogenesis of human hepatocellular carcinoma (HCC) and …

Tamoxifen (TAM) resistance is a serious clinical problem in the treatment of breast cancer.
Here, we found that S-adenosylmethionine (SAM) and DNA methyltransferase1 (DNMT1) …

The farnesoid-X-receptor (FXR) is validated target in the cholestatic disorders treatment.
Obeticholic acid (OCA), the first in class of FXR agonist approved for clinical use, causes …

Alcohol consumption alters factors that modify gene expression without changing the DNA
code (ie, epigenetic modulators) in many organ systems, including the immune system …

Chronic inflammation is an underlying risk factor for colon cancer. Tumor necrosis factor
alpha (TNF-α) plays a critical role in the development of inflammation-induced colon cancer …

Background Liver Hepatocellular Carcinoma (LIHC) is one of the major cancers worldwide,
responsible for millions of premature deaths every year. Prediction of clinical staging is vital …

Methylenetetrahydrofolate reductase (MTHFR) and thymidylate synthase (TYMS) are known
to play a role in DNA methylation, synthesis, and repair. The genetic mutations in MTHFR …

Chronic, heavy alcohol consumption is associated with serious negative health effects,
including the development of several cancer types. One of the pathways affected by alcohol …

Alcohol drinking is a major etiological factor of oro-esophageal squamous cell carcinoma
(OESCC). Both local and systemic effects of ethanol may promote carcinogenesis …

Increased expression of the small nucleolar RNA host gene 6 (SNHG6) has been reported
in different cancers, such as hepatocellular carcinoma, colorectal cancer, and lung cancer …