Emerging Role of One-Carbon Metabolism and DNA Methylation Enrichment on δ-Containing GABAA Receptor Expression in the Cerebellum of Subjects with …
Background Cerebellum is an area of the brain particularly sensitive to the effects of acute
and chronic alcohol consumption. Alcohol exposure decreases cerebellar Purkinje cell …
and chronic alcohol consumption. Alcohol exposure decreases cerebellar Purkinje cell …
Targeting DNA hypomethylation in malignancy by epigenetic therapies
N Mahmood, SA Rabbani - Human Cell Transformation: Advances in Cell …, 2019 - Springer
DNA methylation is a chemically reversible epigenetic modification that regulates the
chromatin structure and gene expression, and thereby takes part in various cellular …
chromatin structure and gene expression, and thereby takes part in various cellular …
The X protein of hepatitis B virus inhibits apoptosis in hepatoma cells through enhancing the methionine adenosyltransferase 2A gene expression and reducing S …
Q Liu, J Chen, L Liu, J Zhang, D Wang, L Ma… - Journal of Biological …, 2011 - ASBMB
The X protein (HBx) of hepatitis B virus (HBV) is involved in the development of
hepatocellular carcinoma (HCC), and methionine adenosyltransferase 2A (MAT2A) …
hepatocellular carcinoma (HCC), and methionine adenosyltransferase 2A (MAT2A) …
Methionine adenosyltransferase 2A regulates mouse zygotic genome activation and morula to blastocyst transition
H Sun, J Kang, J Su, J Zhang, L Zhang… - Biology of …, 2019 - academic.oup.com
Abstract Methionine adenosyltransferase II (MAT2A) is essential to the synthesis of S-
adenosylmethionine, a major methyl donor, from L-methionine and ATP. Upon fertilization …
adenosylmethionine, a major methyl donor, from L-methionine and ATP. Upon fertilization …
Glutathione and transsulfuration in alcohol-associated tissue injury and carcinogenesis
Y Chen, M Han, A Matsumoto, Y Wang… - Alcohol and Cancer …, 2018 - Springer
Glutathione (GSH) is the most abundant non-protein thiol, attaining cellular concentrations in
the millimolar range. GSH functions to protect cells against endogenous and exogenous …
the millimolar range. GSH functions to protect cells against endogenous and exogenous …
Epigenetic aberrations of gene expression in a rat model of hepatocellular carcinoma
Hepatocellular carcinoma (HCC) is mostly triggered by environmental and life-style factors
and may involve epigenetic aberrations. However, a comprehensive documentation of the …
and may involve epigenetic aberrations. However, a comprehensive documentation of the …
Methionine adenosyltransferase (S-adenosylmethionine synthetase)
MA Pajares, GD Markham - … in enzymology and related areas of …, 2011 - Wiley Online Library
Methionine adenosyltransferase (S-adenosylmethionine synthetase) Page 465 P1: TIX/OSW
P2: ABC JWBS076-11 JWBS076-Toone August 21, 2011 10: 15 Printer Name: Yet to Come …
P2: ABC JWBS076-11 JWBS076-Toone August 21, 2011 10: 15 Printer Name: Yet to Come …
S-Adenosylmethionine and methylthioadenosine inhibit cellular FLICE inhibitory protein expression and induce apoptosis in colon cancer cells
TWH Li, Q Zhang, P Oh, M Xia, H Chen… - Molecular …, 2009 - ASPET
S-Adenosylmethionine (SAMe) and its metabolite 5′-methylthioadenosine (MTA) inhibit
mitogen-induced proliferative response in liver and colon cancer cells. SAMe and MTA are …
mitogen-induced proliferative response in liver and colon cancer cells. SAMe and MTA are …
The methionine salvage pathway-involving ADI1 inhibits hepatoma growth by epigenetically altering genes expression via elevating S-adenosylmethionine
Abstract The 5′-methylthioadenosine (MTA) cycle-participating human acireductone
dioxygenase 1 (ADI1) has been implicated as a tumor suppressor in prostate cancer, yet its …
dioxygenase 1 (ADI1) has been implicated as a tumor suppressor in prostate cancer, yet its …
Pharmacological methyl group donors block skeletal metastasis in vitro and in vivo
N Shukeir, B Stefanska, S Parashar… - British journal of …, 2015 - Wiley Online Library
Background and Purpose DNA hypomethylation was previously implicated in metastasis. In
the present study, we examined whether methyl supplementation with the universal methyl …
the present study, we examined whether methyl supplementation with the universal methyl …