The BTB/POZ-ZF [Broad complex, Tramtrack, Bric à brac (BTB) or poxvirus and zinc finger
(POZ)-zinc finger] protein family comprises a diverse group of transcription factors. POZ-ZF …

Summary β-catenin-dependent or canonical Wnt signals are fundamental in animal
development and tumor progression. Using Xenopus laevis, we report that the BTB/POZ zinc …

Abstract β-catenin is widely regarded as the primary transducer of canonical WNT signals to
the nucleus. In most vertebrates, there are eight additional catenins that are structurally …

Bacterial LPS triggers dramatic changes in gene expression in macrophages. We show here
that LPS regulated several members of the histone deacetylase (HDAC) family at the mRNA …

Abstract Class I Histone deacetylases (HDACs) play a central role in controlling cell cycle
regulation, cell differentiation, and tissue development. These enzymes exert their function …

Co-repressor proteins, such as SMRT and NCoR, mediate the repressive activity of
unliganded nuclear receptors and other transcription factors. They appear to act as …

Epigenetic gene silencing is one of the fundamental mechanisms for ensuring proper gene
expression patterns during cellular differentiation and development. Histone deacetylases …

Eukaryotic transcriptional repressors function by recruiting large coregulatory complexes
that target histone deacetylase enzymes to gene promoters and enhancers. Transcriptional …

Although multiple studies have revealed that gallic acid plays an important role in the
inhibition of malignant transformation, cancer development, and inflammation, the molecular …

Toll-like receptors (TLRs) function as initiators of inflammation through their ability to sense
pathogen-associated molecular patterns and products of tissue damage,. Transcriptional …