Aberrant CpG methylation of tumor suppressor gene regulatory elements is associated with
transcriptional silencing and contributes to malignant transformation of different tissues. It is …

Hematopoietic development is governed by the coordinated expression of lineage-and
differentiation stage-specific genes. Transcription factors play major roles in this process and …

The last decade has seen an incredible breakthrough in technologies that allow histones,
transcription factors (TFs), and RNA polymerases to be precisely mapped throughout the …

Vitamin A derivatives plays a crucial role in embryonic development, as demonstrated by the
teratogenic effect of either an excess or a deficiency in vitamin A. Retinoid effects extend …

Spermatogonial stem cells (SSCs) maintain spermatogenesis throughout adulthood through
balanced self-renewal and differentiation, yet the regulatory logic of these fate decisions is …

Transforming growth factor-β1, the key ligand of Smad-dependent signaling pathway, is
critical for epithelial–mesenchymal transition during embryo-morphogenesis, fibrotic …

Methylated DNA can be specifically recognized by a set of proteins called methyl-CpG-
binding proteins (MBPs), which belong to three different structural families in mammals: the …

A long path, initiated more than 40 years ago, has led to a deeper understanding of the
complexity of gene regulation in eukaryotic genomes. In addition to genetic mechanisms, the …

Wnts are conserved, secreted signaling proteins that can influence cell behavior by
stabilizing β-catenin. Accumulated β-catenin enters the nucleus, where it physically …

Dysregulation of Wnt signaling has been implicated in tumorigenesis. The role of Transducin
β-like proteins TBL1-TBLR1 in the promotion of Wnt/β-catenin-mediated oncogenesis has …