Epigenetic modifications on chromatin play important roles in regulating gene expression.
Although chromatin states are often governed by multilayered structure, how individual …

Kaiso belongs to the zinc finger and broad-complex, tramtrack and bric-a-brac/poxvirus and
zinc finger (BTB/POZ) protein family that has been implicated in tumorigenesis. Kaiso was …

Rapsyn is a synapse-specific protein that is required for clustering acetylcholine receptors at
the neuromuscular junction. Analysis of the rapsyn promoter revealed a consensus site for …

p120-catenin exists in a membrane-associated cadherin-bound pool, a cytosolic pool that
affects Rho GTPases, and a nuclear pool that is thought to associate with the methylation …

As most metabolic studies are conducted in male animals, understanding the sex specificity
of the underlying molecular pathways has been broadly neglected; for example, whether …

DNA methylation is a stable epigenetic mark in plant and vertebrate genomes; it is
implicated in regulation of higher order chromatin structure, maintenance of genome …

Epigenetic misregulation is a more common feature in human cancer than previously
anticipated. In the present investigation, we identified CCCTC-binding factor (CTCF), the …

The concept that the brain differs in make-up between males and females is not new. For
example, it is well established that anatomists in the nineteenth century found sex …

Studies with murine models suggest that maternal exposure to aromatic hydrocarbon
receptor (AhR) agonists may impair mammary gland differentiation and increase the …

Clonal hematopoiesis results from somatic mutations in cancer driver genes in
hematopoietic stem cells. We sought to identify novel drivers of clonal expansion using an …