Pulmonary hypertension is defined as a resting mean pulmonary artery pressure of 25 mm
Hg or above. This review deals with pulmonary arterial hypertension (PAH), a type of …

The aging process worsens the human body functions at multiple levels, thus causing its
gradual decrease to resist stress, damage, and disease. Besides changes in gene …

Hypoxic pulmonary vasoconstriction (HPV) is a homeostatic mechanism that is intrinsic to
the pulmonary vasculature. Intrapulmonary arteries constrict in response to alveolar hypoxia …

Abstract The European Cooperation in Science and Technology (COST) provides an ideal
framework to establish multi-disciplinary research networks. COST Action BM1203 (EU …

Background: Right ventricular (RV) adaptation to acute and chronic pulmonary hypertensive
syndromes is a significant determinant of short-and long-term outcomes. Although …

Excessive reactive oxygen species Revised abstract, especially superoxide anion (O2•−),
play important roles in the pathogenesis of many cardiovascular diseases, including …

Pulmonary arterial hypertension is a progressive disorder in which endothelial dysfunction
and vascular remodeling obstruct small pulmonary arteries, resulting in increased …

The right ventricle (RV) is the major determinant of functional state and prognosis in
pulmonary arterial hypertension. RV hypertrophy (RVH) triggered by pressure overload is …

Pathways that sense a reduction in available oxygen are critical in the adaptation to lower
oxygen tensions at high altitude. Alterations in this system can contribute to the …

Knowledge of the pathobiology of pulmonary hypertension (PH) continues to accelerate.
However, fundamental gaps remain in our understanding of the underlying pathological …