The replication of the chromosome is among the most essential functions of the bacterial cell
and influences many other cellular mechanisms, from gene expression to cell division. Yet …

Three DNA polymerases are thought to function at the eukaryotic DNA replication fork.
Currently, a coherent model has been derived for the composition and activities of the …

The archaeal DNA replication machinery bears striking similarity to that of eukaryotes and is
clearly distinct from the bacterial apparatus. In recent years, considerable advances have …

Eukaryotic chromosomes possess multiple origins of replication, whereas bacterial
chromosomes are replicated from a single origin. The archaeon Pyrococcus abyssi also …

In all kingdoms of life, DNA is used to encode hereditary information. Propagation of the
genetic material between generations requires timely and accurate duplication of DNA by …

The hyperthermophilic euryarchaeon Pyrococcus abyssi and the related species
Pyrococcus furiosus and Pyrococcus horikoshii, whose genomes have been completely …

Replication of chromosomes is one of the central events in the cell cycle. Chromosome
replication begins at specific sites, called origins of replication (oriCs), for all three domains …

Since the first archaeal genome was sequenced, much attention has been focused on the
study of these unique microorganisms. We have learnt that although archaeal DNA …

▪ Abstract Genome sequences of a number of archaea have revealed an apparent paradox
in the phylogenies of the bacteria, archaea, and eukarya, as well as an intriguing set of …

DNA replication in archaea and in eukaryotes share many similarities. We report the
structure of an archaeal origin recognition complex protein, ORC1, bound to an origin …