Oxidative stress (OS) has the ability to damage different molecules and cellular structures,
altering the correct function of organs and systems. OS accumulates in the body by …

Glutamine is a multifaceted amino acid used for hepatic urea synthesis, renal
ammoniagenesis, gluconeogenesis in both liver and kidney, and as a major respiratory fuel …

Methotrexate (MTX) is a drug which is used to treat different types of cancers but
hepatotoxicity limits its clinical use. Chlorogenic acid (CGA) is one of the most abundant …

Iron is indispensable for cancer cell survival and cancer cells are more vulnerable to
ferroptosis than normal cells. Ferroptosis holds promise for overcoming chemoresistance …

Drug-induced nephrotoxicity contributes to acute kidney injury (AKI) and represents a major
problem in the clinical setting. We investigated the possible involvement of NLRP3 …

Berberine (BBR) is a natural isoquinoline alkaloid with very impressive health benefits. It is
one of the most effective natural supplements available; however, its ameliorative …

Introduction: Methotrexate, a folate antimetabolite, immunosuppressant and cytotoxic
chemotherapeutic agents employed for malignant conditions. Continuous exposure of …

We report the development of a biostable methotrexate‐immobilized iron oxide nanoparticle
drug carrier that may potentially be used for real‐time monitoring of drug delivery through …

Silymarin (SLY) and naringin (NRG) are natural flavonoids that have been reported to have
many benefits and medicinal properties. The present study was designed to investigate the …

Regarding the mechanisms of methotrexate (MTX) hepatotoxicity and nephrotoxicity, several
hypotheses have been put forward, among which oxidative stress (including depletion of …