Pharmacologic management of aneurysms

JH Lindeman, JS Matsumura - Circulation research, 2019 - Am Heart Assoc
Current management of aortic aneurysms relies exclusively on prophylactic operative repair
of larger aneurysms. Great potential exists for successful medical therapy that halts or …

Pharmacotherapy in clinical trials for abdominal aortic aneurysms: A systematic review and meta-analysis

Z Su, J Guo, Y Gu - Clinical and Applied Thrombosis …, 2022 - journals.sagepub.com
Objective There is no medical treatment proven to limit abdominal aortic aneurysm (AAA)
progression. This systematic review aimed to summarise available trial evidence on the …

An evaluation of the effect of an angiotensin-converting enzyme inhibitor on the growth rate of small abdominal aortic aneurysms: a randomized placebo-controlled …

CD Bicknell, G Kiru, E Falaschetti… - European heart …, 2016 - academic.oup.com
Aims The AARDVARK (Aortic Aneurysmal Regression of Dilation: Value of ACE-Inhibition
on RisK) trial investigated whether ACE-inhibition reduces small abdominal aortic …

ACE inhibitors potently reduce vascular inflammation, results of an open proof-of-concept study in the abdominal aortic aneurysm

KE Kortekaas, CA Meijer, JW Hinnen, RL Dalman… - PloS one, 2014 - journals.plos.org
Background Independent of their blood pressure lowering effect, ACE inhibitors are thought
to reduce vascular inflammation. The clinical relevance of this effect is unclear with the …

Angiotensin II and abdominal aortic aneurysms: an update

J Liu, A Daugherty, H Lu - Current pharmaceutical design, 2015 - ingentaconnect.com
Abdominal aortic aneurysm (AAA) is a devastating disease associated with high prevalence
of death due to aortic rupture. Currently the therapy is restricted to surgical procedures to …

A novel hypothesis: A role for follicle stimulating hormone in abdominal aortic aneurysm development in postmenopausal women

VN Tedjawirja, M Nieuwdorp, KK Yeung… - Frontiers in …, 2021 - frontiersin.org
An abdominal aortic aneurysm (AAA) is a dilatation of the abdominal aorta, which can
potentially be fatal due to exsanguination following rupture. Although AAA is less prevalent …

[HTML][HTML] Prevention of abdominal aortic aneurysm progression by oral administration of green tea polyphenol in a rat model

S Setozaki, K Minakata, H Masumoto, S Hirao… - Journal of Vascular …, 2017 - Elsevier
Objective Inflammation-mediated elastin destruction in the aortic medial layer is related to
progression of abdominal aortic aneurysm (AAA). Epigallocatechin-3-gallate (EGCG), a …

Therapeutic prospect of adipose-derived stromal cells for the treatment of abdominal aortic aneurysm

M Parvizi, MC Harmsen - Stem cells and development, 2015 - liebertpub.com
Aneurysm refers to the dilation of the vessel wall for more than 50%. Abdominal aortic
aneurysm (AAA) refers to the dilation and weakening of all three layers of the abdominal …

[HTML][HTML] Collaborative optimization model for the design and operation of feeder bus routes based on urban metro

Y Lai, Y Chen - Journal of Advanced Transportation, 2023 - hindawi.com
The collaborative development of conventional buses and urban metro has become an
important research topic for the priority development of urban public transport. The topic of …

Inhibition of smooth muscle cell death by Angiotensin 1-7 protects against abdominal aortic aneurysm

AS Jadli, KP Gomes, NN Ballasy… - Bioscience …, 2023 - portlandpress.com
Abdominal aortic aneurysm (AAA) represents a debilitating vascular disease characterized
by aortic dilatation and wall rupture if it remains untreated. We aimed to determine the effects …