We now know that cancer is many different diseases, with great variation even within a
single histological subtype. With the current emphasis on developing personalized …

Despite their known importance in clinical medicine, differences based on sex and gender
are among the least studied factors affecting cancer susceptibility, progression, survival, and …

Genetic syndromes frequently present with overlapping clinical features and inconclusive or
ambiguous genetic findings which can confound accurate diagnosis and clinical …

Although compositional variation in the gut microbiome during human development has
been extensively investigated, strain-resolved dynamic changes remain to be fully …

Background: Characterization of the epigenome is a primary interest for children's
environmental health researchers studying the environmental influences on human …

Mental disorders are highly complex and multifactorial in origin, comprising an elaborate
interplay of genetic and environmental factors. Epigenetic mechanisms such as DNA …

Abstract Background Type 2 diabetes (T2D) is a multifactorial, polygenic disease caused by
impaired insulin secretion and insulin resistance. Genome-wide association studies (GWAS) …

Epigenetic markers are potential biomarkers for diabetes and related complications. Using a
prospective cohort from the Hong Kong Diabetes Register, we perform two independent …

Background Sex differences are known to play a role in disease aetiology, progression and
outcome. Previous studies have revealed autosomal epigenetic differences between males …

Epigenetics refers to mitotically heritable changes to the DNA, which do not affect the DNA
sequence, but can influence its function. Currently, DNA methylation is the most studied …