Astrocytes are abundant glial cells in the central nervous system (CNS) that perform diverse
functions in health and disease. Astrocyte dysfunction is found in numerous diseases …

Cancer development is driven by the accumulation of alterations affecting the structure and
function of the genome. Whereas genetic changes disrupt the DNA sequence, epigenetic …

Abstract N 6-methyladenosine (m6A) is the most abundant RNA modification in mammalian
cells and the best-studied epitranscriptomic mark. Despite the development of various tools …

Cytosine methylation efficiently silences CpG-rich regulatory regions of genes and repeats
in mammalian genomes. To what extent this entails direct inhibition of transcription factor …

Over time, the human DNA methylation landscape accrues substantial damage, which has
been associated with a broad range of age-related diseases, including cardiovascular …

More than 800 million people suffer from kidney disease, yet the mechanism of kidney
dysfunction is poorly understood. In the present study, we define the genetic association with …

Epigenetic mechanisms play vital roles not only in cancer initiation and progression, but also
in the activation, differentiation and effector function (s) of immune cells. In this review, we …

Epigenetic mechanisms, which include DNA methylation, histone modification, and
microRNA (miRNA), can produce heritable phenotypic changes without a change in DNA …

Epigenetic alternations concern heritable yet reversible changes in histone or DNA
modifications that regulate gene activity beyond the underlying sequence. Epigenetic …

Single-cell RNA sequencing has revealed extensive transcriptional cell state diversity in
cancer, often observed independently of genetic heterogeneity, raising the central question …