Early stages of mammalian embryonic development are now known to be very sensitive to
their microenvironment, with long term effects on fetal, postnatal, and adult health, thus …

Sperm cells have long been known to be good producers of reactive oxygen species, while
they are also known to be particularly sensitive to oxidative damage affecting their structures …

Hydroxymethylcytosine (hmC) is an oxidation product of 5-methylcytosine which is present
in the deoxyribonucleic acid (DNA) of most mammalian cells. Reduction of hmC levels in …

Epigenetic inheritance is more widespread in plants than in mammals, in part because
mammals erase epigenetic information by germline reprogramming. We sequenced the …

Zygotic epigenetic reprogramming entails genome-wide DNA demethylation that is
accompanied by Tet methylcytosine dioxygenase 3 (Tet3)-driven oxidation of 5 …

Background Reactive oxygen species (ROS)-induced oxidative stress is well known to play
a major role in male infertility. Sperm are sensitive to ROS damaging effects because as …

The prevalence of overweight and obesity in reproductive-aged men is increasing
worldwide, with> 70% of men> 18 years classified as overweight or obese in some western …

Epigenetic reprogramming of the parental genomes upon fertilization is required for proper
embryonic development. It has long been appreciated that asymmetric distribution of histone …

Background DNA methylation in mammals is an epigenetic mark necessary for normal
embryogenesis. During development active loss of methylation occurs in the male …

DNA methylation, an epigenetic mechanism is claimed to play essential roles in
development, aging and disease over the past few decades. Cytosines (C) were known to …