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Genetic screens for cell division cycle mutants in the filamentous fungus Aspergillus
nidulans led to the discovery of never-in-mitosis A (NIMA), a serine/threonine kinase that is …

Defects in the function of cellular organelles such as peroxisomes, lysosomes and
mitochondria are well-known causes of human diseases. Recently, another organelle has …

Cilia are complex structures that have garnered interest because of their roles in vertebrate
development and their involvement in human genetic disorders. In contrast to multicellular …

Cilia and flagella are widespread cell organelles that have been highly conserved
throughout evolution and play important roles in motility, sensory perception, and the life …

The αβ-tubulin heterodimer, the building block of microtubules, is subject to a large number
of post-translational modifications, comparable in diversity to the intensively studied histone …

Nephronophthisis (NPHP), a recessive cystic kidney disease, is the most frequent genetic
cause of end-stage kidney disease in children and young adults. Positional cloning of nine …

Spinal muscular atrophy (SMA) is an autosomal recessive disorder characterized by a loss
of α motoneurons in the spinal cord. SMA is caused by low levels of the ubiquitously …

Cilia and flagella are highly conserved eukaryotic microtubule-based organelles that
protrude from the surface of most mammalian cells. These structures require large protein …

Abstract Background The trypanosomatids Leishmania major, Trypanosoma brucei and
Trypanosoma cruzi cause some of the most debilitating diseases of humankind: cutaneous …