S-adenosylmethionine (AdoMet, also known as SAM and SAMe) is the principal biological
methyl donor synthesized in all mammalian cells but most abundantly in the liver …

S-adenosyl-l-methionine (SAMe; AdoMet) is an important, metabolically pleiotropic molecule
that participates in multiple cellular reactions as the precursor for the synthesis of glutathione …

Genome sequence analysis reveals that all organisms synthesize S-adenosylmethionine
(AdoMet) and that a large fraction of all genes is AdoMet-dependent methyltransferases …

Liver-specific and nonliver-specific methionine adenosyltransferases (MATs) are products of
two genes, MAT1A and MAT2A, respectively, that catalyze the formation of S …

In the early 1930s, Banting and Best, the discoverers of insulin, found that choline could
prevent the development of fatty liver disease (steatosis) in pancreatectomized dogs treated …

Methionine is an essential amino acid that is metabolized mainly by the liver where it is
converted to S-adenosylmethionine (SAMe) by the enzyme methionine adenosyltransferase …

In mammals, methionine metabolism occurs mainly in the liver via methionine
adenosyltransferase‐catalyzed conversion to S‐adenosylmethionine. Of the two genes that …

Different types of hepatic tissue, including whole or split livers from organ donors or waste
liver from therapeutic liver resections, are used to prepare human hepatocyte cultures …

Deficiencies in vitamins or other factors (B6, B12, folic acid, betaine) and genetic disorders
for the metabolism of the non-protein amino acid-homocysteine (Hcy) lead to …

Abstract S‐Adenosylmethionine (SAMe), the principal biological methyl donor, is
synthesized from methionine and ATP in a reaction catalyzed by methionine …