Metabolic regulatory properties of S-adenosylmethionine and S-adenosylhomocysteine
JD Finkelstein - 2007 - degruyter.com
In mammalian liver, two intersecting pathways, remethylation and transsulfuration, compete
for homocysteine that has been formed from methionine. Remethylation of homocysteine …
for homocysteine that has been formed from methionine. Remethylation of homocysteine …
Hypoxia induces genomic DNA demethylation through the activation of HIF-1α and transcriptional upregulation of MAT2A in hepatoma cells
Q Liu, L Liu, Y Zhao, J Zhang, D Wang, J Chen… - Molecular cancer …, 2011 - AACR
Abstract Hypoxia-inducible factor 1 (HIF-1) emerges as a crucial player in tumor
progression. However, its role in hepatocellular carcinoma (HCC), especially its relation with …
progression. However, its role in hepatocellular carcinoma (HCC), especially its relation with …
Functional proteomics of nonalcoholic steatohepatitis: Mitochondrial proteins as targets of S-adenosylmethionine
E Santamaría, MA Avila, MU Latasa… - Proceedings of the …, 2003 - National Acad Sciences
Recent work shows that S-adenosylmethionine (AdoMet) helps maintain normal liver
function as chronic hepatic deficiency results in spontaneous development of steatohepatitis …
function as chronic hepatic deficiency results in spontaneous development of steatohepatitis …
S-adenosylmethionine and its products
MA Grillo, S Colombatto - Amino acids, 2008 - Springer
S-adenosylmethionine is involved in many processes, mainly methylation, polyamine
synthesis and radical-based catalysis. It is synthesised through the catalysis of differently …
synthesis and radical-based catalysis. It is synthesised through the catalysis of differently …
Role of methionine adenosyltransferase and S-adenosylmethionine in alcohol-associated liver cancer
SC Lu, JM Mato - Alcohol, 2005 - Elsevier
Two genes (MAT1A and MAT2A) encode for the essential enzyme methionine
adenosyltransferase (MAT), which catalyzes the biosynthesis of S-adenosylmethionine …
adenosyltransferase (MAT), which catalyzes the biosynthesis of S-adenosylmethionine …
[HTML][HTML] Smartamine M and MetaSmart supplementation during the peripartal period alter hepatic expression of gene networks in 1-carbon metabolism, inflammation …
Peripartal cows likely require greater amounts of Met not only at the tissue and cell level for
methylation reactions but also for milk protein synthesis after calving. Thirty-nine Holstein …
methylation reactions but also for milk protein synthesis after calving. Thirty-nine Holstein …
S-adenosylmethionine and methylthioadenosine are antiapoptotic in cultured rat hepatocytes but proapoptotic in human hepatoma cells
E Ansorena, ER Garcıa-Trevijano… - Hepatology, 2002 - Elsevier
S-adenosylmethionine (AdoMet) is an essential compound in cellular transmethylation
reactions and a precursor of polyamine and glutathione synthesis in the liver. In liver injury …
reactions and a precursor of polyamine and glutathione synthesis in the liver. In liver injury …
Methionine adenosyltransferases in cancers: Mechanisms of dysregulation and implications for therapy
LY Maldonado, D Arsene, JM Mato… - … Biology and Medicine, 2018 - journals.sagepub.com
Methionine adenosyltransferase genes encode enzymes responsible for the biosynthesis of
S-adenosylmethionine, the principal biological methyl donor and precursor of polyamines …
S-adenosylmethionine, the principal biological methyl donor and precursor of polyamines …
HuR/methyl-HuR and AUF1 regulate the MAT expressed during liver proliferation, differentiation, and carcinogenesis
M Vázquez–Chantada, D Fernández–Ramos… - Gastroenterology, 2010 - Elsevier
BACKGROUND & AIMS: Hepatic de-differentiation, liver development, and malignant
transformation are processes in which the levels of hepatic S-adenosylmethionine are tightly …
transformation are processes in which the levels of hepatic S-adenosylmethionine are tightly …
[HTML][HTML] Methionine adenosyltransferases in liver cancer
B Murray, L Barbier-Torres, W Fan… - World journal of …, 2019 - ncbi.nlm.nih.gov
Methionine adenosyltransferases (MATs) are essential enzymes for life as they produce S-
adenosylmethionine (SAMe), the biological methyl donor required for a plethora of reactions …
adenosylmethionine (SAMe), the biological methyl donor required for a plethora of reactions …