Targeting the methionine cycle for melanoma therapy with 3‐O‐(3,4,5‐trimethoxybenzoyl)‐(−)‐epicatechin
L Sánchez‐del‐Campo… - International journal of …, 2008 - Wiley Online Library
The higher expression of methionine cycle genes in melanoma cells than in normal
melanocytes may be related with increased protein synthesis and transmethylation reactions …
melanocytes may be related with increased protein synthesis and transmethylation reactions …
Resveratrol supplementation worsen the dysregulation of genes involved in hepatic lipid homeostasis observed in hyperhomocysteinemic mice
C Noll, J Hamelet, V Ducros, N Belin, JL Paul… - Food and chemical …, 2009 - Elsevier
Hyperhomocysteinemia is characterized by an increase of plasma homocysteine, a thiol-
containing amino acid produced during methionine metabolism. Hyperhomocysteinemia …
containing amino acid produced during methionine metabolism. Hyperhomocysteinemia …
Influence of impaired liver methionine metabolism on the development of vascular disease and inflammation
MA Avila, C Berasain, J Prieto, JM Mato… - Current Medicinal …, 2005 - ingentaconnect.com
Methionine (Met) metabolism involves the sequential formation of S-adenosylmethionine
(SAM, the main biological methyl donor), S-adenosylhomocysteine (SAH) and homocysteine …
(SAM, the main biological methyl donor), S-adenosylhomocysteine (SAH) and homocysteine …
Opposite action of S-adenosyl methionine and its metabolites on CYP2E1-mediated toxicity in pyrazole-induced rat hepatocytes and HepG2 E47 cells
D Wu, AI Cederbaum - American Journal of Physiology …, 2006 - journals.physiology.org
S-adenosyl-l-methionine (SAMe) is protective against a variety of hepatotoxins, including
ethanol. The ability of SAMe to protect against cytochrome P-450 2E1 (CYP2E1)-dependent …
ethanol. The ability of SAMe to protect against cytochrome P-450 2E1 (CYP2E1)-dependent …
Gene switching in Amoeba proteus caused by endosymbiotic bacteria
TJ Jeon, KW Jeon - Journal of Cell Science, 2004 - journals.biologists.com
The expression of genes for S-adenosylmethionine synthetase (SAMS), which catalyzes the
synthesis of S-adenosylmethionine (AdoMet), a major methyl donor in cells, was studied in …
synthesis of S-adenosylmethionine (AdoMet), a major methyl donor in cells, was studied in …
Proteinase-activated receptor 2 promotes 3T3-L1 preadipocyte differentiation through activation of the PI3K/AKT signalling pathway and MAT2A gene expression
X Wang, F Liang, H Fan, Z Wang, X Gou… - Archives of Physiology …, 2020 - Taylor & Francis
The present study aimed to investigate the function and mechanisms of PAR2 in
preadipocyte differentiation. This study found that the expression level of PAR2 was …
preadipocyte differentiation. This study found that the expression level of PAR2 was …
Molecular Profiling of Hepatocellular Carcinoma in Mice with a Chronic Deficiency of Hepatic S-Adenosylmethionine: Relevance in Human Liver Diseases
E Santamaría, J Muñoz… - Journal of proteome …, 2006 - ACS Publications
S-adenosylmethionine arises as a central molecule in the preservation of liver homeostasis
as a chronic hepatic deficiency results in spontaneous development of steatohepatitis and …
as a chronic hepatic deficiency results in spontaneous development of steatohepatitis and …
Proteomic analysis of human hepatoma cells expressing methionine adenosyltransferase I/III: Characterization of DDX3X as a target of S-adenosylmethionine
PC Schröder, J Fernández-Irigoyen, E Bigaud… - Journal of …, 2012 - Elsevier
Methionine adenosyltransferase I/III (MATI/III) synthesizes S-adenosylmethionine (SAM) in
quiescent hepatocytes. Its activity is compromised in most liver diseases including liver …
quiescent hepatocytes. Its activity is compromised in most liver diseases including liver …
Betaine-Homocysteine S-Methyl-Transferase (BHMT) Transcription is Inhibited by S-Adenosylmethionine (AdoMet)
C Castro, AP Breksa, EM Salisbury… - Chemistry and Biology of …, 2002 - Springer
Betaine-homocysteine S-methyltransferase (BHMT)(EC 2.1. 1.5) is a zinc metalloenzyme
that is predominantly expressed in liver. This enzyme participates in homocysteine (Hcy) …
that is predominantly expressed in liver. This enzyme participates in homocysteine (Hcy) …