The hypothalamus-pituitary-adrenal axis (HPA) is essential in the regulation of stress
responses. Increased methylation of the promoter region of the glucocorticoid receptor gene …

The term “epigenetics” refers to modifications in gene expression caused by heritable, but
potentially reversible, changes in DNA methylation and chromatin structure. Given the fact …

Prenatal synthetic glucocorticoids (sGC) are administered to pregnant women at risk of
delivering preterm, approximately 10% of all pregnancies. Animal studies have …

Major Depressive Disorder (MDD) entails a multifactorial disorder of rising prevalence.
Nearly 280 million people suffer from this leading cause of disability in the world. Moreover …

Maternal obesity plays a key role in the health trajectory of the offspring. Although research
on this topic has largely focused on the potential of this condition to increase the risk for child …

Dietary interventions like gluten-free and casein-free diets have been reported to improve
intestinal, autoimmune and neurological symptoms in patients with a variety of conditions; …

Objective Cardiovascular disease (CVD) is the leading cause of death in severe psychiatric
disorders (depression, schizophrenia). Here, we provide evidence of how the effects of …

The unique variability in the 5′ region of the GR gene, with 9 alternative first exons and 13
splice variants plays a critical role in transcriptional control maintaining homeostasis of the …

Maternal obesity and overconsumption of saturated fats during pregnancy have profound
effects on offspring health, ranging from metabolic to behavioral disorders in later life. The …

Biological psychiatry has dominated psychiatric thinking for the past 40 years, but the
knowledge base of the discipline has increased substantially more recently, particularly with …