[HTML][HTML] Causal relationship between gut microbiota and cancers: a two-sample Mendelian randomisation study
Y Long, L Tang, Y Zhou, S Zhao, H Zhu - BMC medicine, 2023 - Springer
Background Evidence from observational studies and clinical trials suggests that the gut
microbiota is associated with cancer. However, the causal association between gut …
microbiota is associated with cancer. However, the causal association between gut …
Linking prenatal environmental exposures to lifetime health with epigenome-wide association studies: state-of-the-science review and future recommendations
Background: The prenatal environment influences lifetime health; epigenetic mechanisms
likely predominate. In 2016, the first international consortium paper on cigarette smoking …
likely predominate. In 2016, the first international consortium paper on cigarette smoking …
Epigenetics applied to child and adolescent mental health: Progress, challenges and opportunities
Background Epigenetic processes are fast emerging as a promising molecular system in the
search for both biomarkers and mechanisms underlying human health and disease risk …
search for both biomarkers and mechanisms underlying human health and disease risk …
[HTML][HTML] Refining epigenetic prediction of chronological and biological age
Background Epigenetic clocks can track both chronological age (cAge) and biological age
(bAge). The latter is typically defined by physiological biomarkers and risk of adverse health …
(bAge). The latter is typically defined by physiological biomarkers and risk of adverse health …
[HTML][HTML] Blood-based epigenome-wide analyses of 19 common disease states: A longitudinal, population-based linked cohort study of 18,413 Scottish individuals
RF Hillary, DL McCartney, HM Smith, E Bernabeu… - PLoS …, 2023 - journals.plos.org
Background DNA methylation is a dynamic epigenetic mechanism that occurs at cytosine-
phosphate-guanine dinucleotide (CpG) sites. Epigenome-wide association studies (EWAS) …
phosphate-guanine dinucleotide (CpG) sites. Epigenome-wide association studies (EWAS) …
[HTML][HTML] Multi-omics signatures of the human early life exposome
L Maitre, M Bustamante, C Hernández-Ferrer… - Nature …, 2022 - nature.com
Environmental exposures during early life play a critical role in life-course health, yet the
molecular phenotypes underlying environmental effects on health are poorly understood. In …
molecular phenotypes underlying environmental effects on health are poorly understood. In …
Arsenic exposure, blood DNA methylation, and cardiovascular disease
A Domingo-Relloso, K Makhani… - Circulation …, 2022 - Am Heart Assoc
Background: Epigenetic dysregulation has been proposed as a key mechanism for arsenic-
related cardiovascular disease (CVD). We evaluated differentially methylated positions …
related cardiovascular disease (CVD). We evaluated differentially methylated positions …
[HTML][HTML] Meta-analyses identify DNA methylation associated with kidney function and damage
Chronic kidney disease is a major public health burden. Elevated urinary albumin-to-
creatinine ratio is a measure of kidney damage, and used to diagnose and stage chronic …
creatinine ratio is a measure of kidney damage, and used to diagnose and stage chronic …
Causality-enriched epigenetic age uncouples damage and adaptation
Abstract Machine learning models based on DNA methylation data can predict biological
age but often lack causal insights. By harnessing large-scale genetic data through …
age but often lack causal insights. By harnessing large-scale genetic data through …
Low-input and single-cell methods for Infinium DNA methylation BeadChips
Abstract The Infinium BeadChip is the most widely used DNA methylome assay technology
for population-scale epigenome profiling. However, the standard workflow requires over 200 …
for population-scale epigenome profiling. However, the standard workflow requires over 200 …