[HTML][HTML] Epigenetic regulation in metabolic diseases: mechanisms and advances in clinical study
YL Wu, ZJ Lin, CC Li, X Lin, SK Shan, B Guo… - … and Targeted Therapy, 2023 - nature.com
Epigenetics regulates gene expression and has been confirmed to play a critical role in a
variety of metabolic diseases, such as diabetes, obesity, non-alcoholic fatty liver disease …
variety of metabolic diseases, such as diabetes, obesity, non-alcoholic fatty liver disease …
[PDF][PDF] Epigenetics in human obesity and type 2 diabetes
Epigenetic mechanisms control gene activity and the development of an organism. The
epigenome includes DNA methylation, histone modifications, and RNA-mediated processes …
epigenome includes DNA methylation, histone modifications, and RNA-mediated processes …
β-cell failure in type 2 diabetes: postulated mechanisms and prospects for prevention and treatment
PA Halban, KS Polonsky, DW Bowden… - The Journal of …, 2014 - academic.oup.com
OBJECTIVE: This article examines the foundation of β-cell failure in type 2 diabetes (T2D)
and suggests areas for future research on the underlying mechanisms that may lead to …
and suggests areas for future research on the underlying mechanisms that may lead to …
Molecular complexities underlying the vascular complications of diabetes mellitus–A comprehensive review
Diabetes is a chronic disease, characterized by hyperglycemia, which refers to the elevated
levels of glucose in the blood, due to the inability of the body to produce or use insulin …
levels of glucose in the blood, due to the inability of the body to produce or use insulin …
[HTML][HTML] A six months exercise intervention influences the genome-wide DNA methylation pattern in human adipose tissue
Epigenetic mechanisms are implicated in gene regulation and the development of different
diseases. The epigenome differs between cell types and has until now only been …
diseases. The epigenome differs between cell types and has until now only been …
[HTML][HTML] Genome-wide DNA methylation analysis of human pancreatic islets from type 2 diabetic and non-diabetic donors identifies candidate genes that influence …
Impaired insulin secretion is a hallmark of type 2 diabetes (T2D). Epigenetics may affect
disease susceptibility. To describe the human methylome in pancreatic islets and determine …
disease susceptibility. To describe the human methylome in pancreatic islets and determine …
Epigenetics of type 2 diabetes mellitus and weight change—a tool for precision medicine?
Pioneering studies performed over the past few decades demonstrate links between
epigenetics and type 2 diabetes mellitus (T2DM), the metabolic disorder with the most …
epigenetics and type 2 diabetes mellitus (T2DM), the metabolic disorder with the most …
Altered DNA methylation and differential expression of genes influencing metabolism and inflammation in adipose tissue from subjects with type 2 diabetes
E Nilsson, PA Jansson, A Perfilyev, P Volkov… - Diabetes, 2014 - Am Diabetes Assoc
Genetics, epigenetics, and environment may together affect the susceptibility for type 2
diabetes (T2D). Our aim was to dissect molecular mechanisms underlying T2D using …
diabetes (T2D). Our aim was to dissect molecular mechanisms underlying T2D using …
Impact of an exercise intervention on DNA methylation in skeletal muscle from first-degree relatives of patients with type 2 diabetes
To identify epigenetic patterns, which may predispose to type 2 diabetes (T2D) due to a
family history (FH) of the disease, we analyzed DNA methylation genome-wide in skeletal …
family history (FH) of the disease, we analyzed DNA methylation genome-wide in skeletal …
Impact of age, BMI and HbA1c levels on the genome-wide DNA methylation and mRNA expression patterns in human adipose tissue and identification of epigenetic …
Increased age, BMI and HbA1c levels are risk factors for several non-communicable
diseases. However, the impact of these factors on the genome-wide DNA methylation …
diseases. However, the impact of these factors on the genome-wide DNA methylation …