Simple Summary Brain tumors comprise a large, varied group, with gliomas being the most
common malignant tumors arising in the brain. This state-of-the-art review discusses the role …

Current molecular biology laboratories rely heavily on the purification and manipulation of
nucleic acids. Yet, commonly used centrifuge-and column-based protocols require …

In the last decade, large-scale genomic studies in patients with hematologic malignancies
identified recurrent somatic alterations in epigenetic modifier genes. Among these, the de …

Dendritic cells (DCs), the most potent antigen-presenting cells, are necessary for effective
activation of naïve T cells. DCs' immunological properties are modulated in response to …

The differentiation of human blood monocytes (MO), the post-mitotic precursors of
macrophages (MAC) and dendritic cells (moDC), is accompanied by the active turnover of …

DNA methylation plays crucial roles in many biological processes and abnormal DNA
methylation patterns are often observed in diseases. Recent studies have shed light on cis …

Organisms adapt to different environments by selection of the most suitable phenotypes from
the standing genetic variation or by phenotypic plasticity, the ability of single genotypes to …

DNA replication stress is a major source of DNA damage, including double-stranded breaks
that promote DNA damage response (DDR) signaling. Inefficient repair of such lesions can …

Hypoxia or reduced oxygen availability has been studied extensively for its ability to activate
specific genes. Hypoxia-induced gene expression is mediated by the HIF transcription …

TET (ten-eleven translocation) enzymes catalyze the oxidation of 5-methylcytosine bases in
DNA, thus driving active and passive DNA demethylation. Here, we report that the catalytic …