[HTML][HTML] DNA methylation and histone modification in low-grade gliomas: current understanding and potential clinical targets
Simple Summary Brain tumors comprise a large, varied group, with gliomas being the most
common malignant tumors arising in the brain. This state-of-the-art review discusses the role …
common malignant tumors arising in the brain. This state-of-the-art review discusses the role …
[HTML][HTML] Bio-On-Magnetic-Beads (BOMB): Open platform for high-throughput nucleic acid extraction and manipulation
Current molecular biology laboratories rely heavily on the purification and manipulation of
nucleic acids. Yet, commonly used centrifuge-and column-based protocols require …
nucleic acids. Yet, commonly used centrifuge-and column-based protocols require …
Alterations to DNMT3A in Hematologic Malignancies
K Venugopal, Y Feng, D Shabashvili, OA Guryanova - Cancer research, 2021 - AACR
In the last decade, large-scale genomic studies in patients with hematologic malignancies
identified recurrent somatic alterations in epigenetic modifier genes. Among these, the de …
identified recurrent somatic alterations in epigenetic modifier genes. Among these, the de …
Vitamin C enhances NF-κB-driven epigenomic reprogramming and boosts the immunogenic properties of dendritic cells
O Morante-Palacios, G Godoy-Tena… - Nucleic Acids …, 2022 - academic.oup.com
Dendritic cells (DCs), the most potent antigen-presenting cells, are necessary for effective
activation of naïve T cells. DCs' immunological properties are modulated in response to …
activation of naïve T cells. DCs' immunological properties are modulated in response to …
[HTML][HTML] The epigenetic pioneer EGR2 initiates DNA demethylation in differentiating monocytes at both stable and transient binding sites
K Mendes, S Schmidhofer, J Minderjahn… - Nature …, 2021 - nature.com
The differentiation of human blood monocytes (MO), the post-mitotic precursors of
macrophages (MAC) and dendritic cells (moDC), is accompanied by the active turnover of …
macrophages (MAC) and dendritic cells (moDC), is accompanied by the active turnover of …
Deciphering the genetic code of DNA methylation
DNA methylation plays crucial roles in many biological processes and abnormal DNA
methylation patterns are often observed in diseases. Recent studies have shed light on cis …
methylation patterns are often observed in diseases. Recent studies have shed light on cis …
[HTML][HTML] Environmental Adaptation of Genetically Uniform Organisms with the Help of Epigenetic Mechanisms—An Insightful Perspective on Ecoepigenetics
G Vogt - Epigenomes, 2022 - mdpi.com
Organisms adapt to different environments by selection of the most suitable phenotypes from
the standing genetic variation or by phenotypic plasticity, the ability of single genotypes to …
the standing genetic variation or by phenotypic plasticity, the ability of single genotypes to …
Interplay between DNA replication stress, chromatin dynamics and DNA-damage response for the maintenance of genome stability
M Mognato, S Burdak-Rothkamm… - … Research/Reviews in …, 2021 - Elsevier
DNA replication stress is a major source of DNA damage, including double-stranded breaks
that promote DNA damage response (DDR) signaling. Inefficient repair of such lesions can …
that promote DNA damage response (DDR) signaling. Inefficient repair of such lesions can …
[HTML][HTML] Hypoxia and chromatin: a focus on transcriptional repression mechanisms
Hypoxia or reduced oxygen availability has been studied extensively for its ability to activate
specific genes. Hypoxia-induced gene expression is mediated by the HIF transcription …
specific genes. Hypoxia-induced gene expression is mediated by the HIF transcription …
Pronounced sequence specificity of the TET enzyme catalytic domain guides its cellular function
M Ravichandran, D Rafalski, CI Davies… - Science …, 2022 - science.org
TET (ten-eleven translocation) enzymes catalyze the oxidation of 5-methylcytosine bases in
DNA, thus driving active and passive DNA demethylation. Here, we report that the catalytic …
DNA, thus driving active and passive DNA demethylation. Here, we report that the catalytic …