Abstract Histone Post-Translational Modifications (PTMs) play fundamental roles in
mediating DNA-related processes such as transcription, replication and repair. The histone …

Alternative non‐B‐DNA conformations formed under physiological conditions by sequences
called flipons include left‐handed Z‐DNA, three‐stranded triplexes, and four‐stranded i …

Epigenetic genome regulation during malignant cell transformation is characterized by the
aberrant methylation and acetylation of histones. Vorinostat (SAHA) is an epigenetic …

Histone lysine methyltransferases (HKMTs) deposit methyl groups onto lysine residues on
histones and play important roles in regulating chromatin structure and gene expression …

Protein lysine methyltransferases (PKMTs) play essential roles in gene expression
regulation and cancer development. Somatic mutations in PKMTs are frequently observed in …

Despite recent advances have been made in clinical treatments of breast cancer, the
general prognosis of patients remains poor. Therefore, it is imperative to develop a more …

Nuclear receptor-binding SET domain 3, otherwise known as NSD3, is a member of the
group of lysine methyltransferases and is involved in a variety of cellular processes …

The multifunctional RNA-binding protein hnRNPL is implicated in antibody class switching
but its broader function in B cells is unknown. Here, we show that hnRNPL is essential for B …

The human protein lysine methyltransferase NSD2 catalyzes dimethylation at H3K36. It has
very important roles in development and disease but many mechanistic features and its full …

Histones are subjected to extensive covalent modifications that affect inter-nucleosomal
interactions as well as alter chromatin structure and DNA accessibility. Through switching …