Primary cilia project in a single copy from the surface of most vertebrate cell types; they
detect and transmit extracellular cues to regulate diverse cellular processes during …

Although tumours initiate from oncogenic changes in a cancer cell, subsequent tumour
progression and therapeutic response depend on interactions between the cancer cells and …

Interventions that delay ageing mobilize mechanisms that protect and repair cellular
components,,, but it is unknown how these interventions might slow the functional decline of …

Primary cilia are specialized microtubule‐based signaling organelles that convey
extracellular signals into a cellular response in most vertebrate cell types. The physiological …

The release of membrane vesicles from the surface of cells into their surrounding
environment is now recognized as an important pathway for the delivery of proteins to …

Background The heat shock response, induced by cytoplasmic proteotoxic stress, is one of
the most highly conserved transcriptional responses. This response, driven by the heat …

Many proteins are known to promote ciliogenesis, but mechanisms that promote primary
cilia disassembly before mitosis are largely unknown. Here we identify a mechanism that …

Alström syndrome (AS) is characterised by metabolic deficits, retinal dystrophy,
sensorineural hearing loss, dilated cardiomyopathy and multi-organ fibrosis. Elucidating the …

Since the beginning of the millennium, research in primary cilia has revolutionized our way
of understanding how cells integrate and organize diverse signaling pathways during …

Mitral valve prolapse (MVP) affects 1 in 40 people and is the most common indication for
mitral valve surgery. MVP can cause arrhythmias, heart failure, and sudden cardiac death …