Biomarker discovery and validation are necessary for improving the prediction of clinical
outcomes and patient monitoring. Despite considerable interest in biomarker discovery and …

Recent research efforts provided compelling evidence of genome-wide DNA methylation
alterations in aging and age-related disease. It is currently well established that DNA …

One of the most critical epigenetic signatures present in the genome of higher eukaryotes is
the methylation of DNA at the C-5 position of the cytosine ring. Based on the sites of DNA …

Neurodegenerative diseases are a major public health problem worldwide with a wide
spectrum of symptoms and physiological effects. It has been long reported that the …

Neurodegenerative diseases are hereditary or sporadic conditions that result in the
progressive loss of the structure and function of neurons as well as neuronal death …

Alzheimer's disease (AD) is a well-known neurodegenerative disorder that imposes a great
burden on the world. The mechanisms of AD are not yet fully understood. Current insight into …

Abstract Background Late-onset Alzheimer's disease (AD) is a complex multifactorial
affliction, the pathogenesis of which is thought to involve gene-environment interactions that …

Research over the years has shown that causes of Alzheimer's disease are not well
understood, but over the past years, the involvement of epigenetic mechanisms in the …

Frailty and cognitive impairment are among the 2 most common geriatric syndromes. Their
presence poses major risks to the elderly including greater disability, reduced quality of life …

Depression (MDD) is prodromal to, and a component of, Alzheimer's disease (AD): it may
also be a trigger for incipient AD. MDD is not a unitary disorder, so there may be particular …