Melanoma is the deadliest form of skin cancer. In the early stages, melanoma can be treated
successfully with surgery alone and survival rates are high, but after metastasis survival …

Long non-coding (lnc) RNAs are non-coding RNAs longer than 200 nt. lncRNAs primarily
interact with mRNA, DNA, protein, and miRNA and consequently regulate gene expression …

Histones are subject to a vast array of posttranslational modifications including acetylation,
methylation, phosphorylation, and ubiquitylation. The writers of these modifications play …

Differential gene expression gives rise to the many cell types of complex organisms.
Enhancers regulate transcription by binding transcription factors (TFs), which in turn recruit …

The function of sperm is to safely transport the haploid paternal genome to the egg
containing the maternal genome. The subsequent fertilization leads to transmission of a new …

Protein methylation is a common posttranslational modification that mostly occurs on
arginine and lysine residues. Arginine methylation has been reported to regulate RNA …

ABSTRACT A vast array of successive epigenetic modifications ensures the creation of a
healthy individual. Crucial epigenetic reprogramming events occur during germ cell …

Chromatin consists of a complex of DNA and histone proteins as its core components and
plays an important role in both packaging DNA and regulating DNA metabolic pathways …

Acute kidney injury (AKI) is a major public health concern associated with high morbidity and
mortality. Despite decades of research, the pathogenesis of AKI remains incompletely …

It has been established that regulation of chromatin structure through post-translational
modification of histone proteins, primarily histone H3 phosphorylation and acetylation, is an …