Significance: The detrimental effects of ionizing radiation (IR) involve a highly orchestrated
series of events that are amplified by endogenous signaling and culminating in oxidative …

The advancements made in tissue culture techniques has made it possible to regenerate
various horticultural species in vitro as micropropagation protocols for commercial scale …

Genomic instability can initiate cancer, augment progression, and influence the overall
prognosis of the affected patient. Genomic instability arises from many different pathways …

Abstract According to the “Developmental Origins of Health and Disease”(DOHaD) concept,
the early-life environment is a critical period for fetal programming. Given the …

The in vitro tissue cultures are, beyond all difficulties, an essential tool in basic research as
well as in commercial applications. Numerous works devoted to plant tissue cultures proved …

▪ Abstract Reactive oxygen intermediates are produced in all aerobic organisms during
respiration and exist in the cell in a balance with biochemical antioxidants. Excess reactive …

Transformation of a normal cell to a malignant one requires phenotypic changes often
associated with each of the initiation, promotion and progression phases of the carcinogenic …

Recent studies have demonstrated the presence of microsatellite instability (MSI) in tumors
from patients with hereditary nonpolyposis colon cancer and in a subset of patients with …

In vitro methods are common and widely used for screening and ranking chemicals, and
have also been taken into account sporadically for risk assessment purposes in the case of …

Epigenetics, the transgenerational transfer of phenotypic characters without modification of
gene sequence, is a burgeoning area of study in many disciplines of biology. However, the …