Anthocyanin as a therapeutic in Alzheimer's disease: A systematic review of preclinical evidences

S Suresh, RF Begum, A Singh, V Chitra - Ageing Research Reviews, 2022 - Elsevier
Background The aim of this systematic review is to ponder the possible mechanism of action
of anthocyanin in Alzheimer's disease (AD), to prompt the development of anthocyanin …

Inflammatory mechanisms in neurodegeneration

MR Nichols, MK St‐Pierre, AC Wendeln… - Journal of …, 2019 - Wiley Online Library
This review discusses the profound connection between microglia, neuroinflammation, and
Alzheimer's disease (AD). Theories have been postulated, tested, and modified over several …

Reactive astrocytes as treatment targets in Alzheimer's disease—systematic review of studies using the APPswePS1dE9 mouse model

T Smit, NAC Deshayes, DR Borchelt, W Kamphuis… - Glia, 2021 - Wiley Online Library
Astrocytes regulate synaptic communication and are essential for proper brain functioning.
In Alzheimer's disease (AD) astrocytes become reactive, which is characterized by an …

Engineering large animal models of human disease

CBA Whitelaw, TP Sheets, SG Lillico… - The Journal of …, 2016 - Wiley Online Library
The recent development of gene editing tools and methodology for use in livestock enables
the production of new animal disease models. These tools facilitate site‐specific mutation of …

[HTML][HTML] Alzheimer's disease: mechanism and approach to cell therapy

T Amemori, P Jendelova, J Ruzicka… - International journal of …, 2015 - mdpi.com
Alzheimer's disease (AD) is the most common form of dementia. The risk of AD increases
with age. Although two of the main pathological features of AD, amyloid plaques and …

The behavioral, pathological and therapeutic features of the senescence-accelerated mouse prone 8 strain as an Alzheimer's disease animal model

X Cheng, W Zhou, Y Zhang - Ageing Research Reviews, 2014 - Elsevier
Alzheimer's disease (AD) is a widespread and devastating progressive neurodegenerative
disease. Disease-modifying treatments remain beyond reach, and the etiology of the …

The effect of ageing on neurogenesis and oxidative stress in the APPswe/PS1deltaE9 mouse model of Alzheimer's disease

A Hamilton, C Holscher - Brain research, 2012 - Elsevier
Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterised by
memory loss and impaired cognitive function. One of the hallmarks of AD is the formation of …

Antimalarial drug Artemisinin extenuates amyloidogenesis and neuroinflammation in APP swe/PS 1dE9 Transgenic Mice via inhibition of nuclear factor‐κ B and NLRP …

JQ Shi, CC Zhang, XL Sun, XX Cheng… - CNS neuroscience & …, 2013 - Wiley Online Library
Background The activation of nuclear factor‐kappa B (NF‐κB) and NLRP 3 inflammasome is
involved in neuroinflammation, which is closely linked to A lzheimer's disease (AD). In vivo …

[HTML][HTML] Retinal capillary degeneration and blood-retinal barrier disruption in murine models of Alzheimer's disease

H Shi, Y Koronyo, DT Fuchs, J Sheyn… - Acta Neuropathologica …, 2020 - Springer
Extensive effort has been made studying retinal pathology in Alzheimer's disease (AD) to
improve early noninvasive diagnosis and treatment. Particularly relevant are vascular …

Antiepileptics topiramate and levetiracetam alleviate behavioral deficits and reduce neuropathology in APP swe/PS 1dE9 transgenic mice

JQ Shi, BR Wang, YY Tian, J Xu, L Gao… - CNS neuroscience & …, 2013 - Wiley Online Library
Background The close relationship between epileptic seizure and Alzheimer's disease (AD)
has been demonstrated in the past decade. Valproic acid, a traditional first‐line antiepileptic …