Anthocyanin as a therapeutic in Alzheimer's disease: A systematic review of preclinical evidences
Background The aim of this systematic review is to ponder the possible mechanism of action
of anthocyanin in Alzheimer's disease (AD), to prompt the development of anthocyanin …
of anthocyanin in Alzheimer's disease (AD), to prompt the development of anthocyanin …
Inflammatory mechanisms in neurodegeneration
MR Nichols, MK St‐Pierre, AC Wendeln… - Journal of …, 2019 - Wiley Online Library
This review discusses the profound connection between microglia, neuroinflammation, and
Alzheimer's disease (AD). Theories have been postulated, tested, and modified over several …
Alzheimer's disease (AD). Theories have been postulated, tested, and modified over several …
Reactive astrocytes as treatment targets in Alzheimer's disease—systematic review of studies using the APPswePS1dE9 mouse model
T Smit, NAC Deshayes, DR Borchelt, W Kamphuis… - Glia, 2021 - Wiley Online Library
Astrocytes regulate synaptic communication and are essential for proper brain functioning.
In Alzheimer's disease (AD) astrocytes become reactive, which is characterized by an …
In Alzheimer's disease (AD) astrocytes become reactive, which is characterized by an …
Engineering large animal models of human disease
CBA Whitelaw, TP Sheets, SG Lillico… - The Journal of …, 2016 - Wiley Online Library
The recent development of gene editing tools and methodology for use in livestock enables
the production of new animal disease models. These tools facilitate site‐specific mutation of …
the production of new animal disease models. These tools facilitate site‐specific mutation of …
[HTML][HTML] Alzheimer's disease: mechanism and approach to cell therapy
T Amemori, P Jendelova, J Ruzicka… - International journal of …, 2015 - mdpi.com
Alzheimer's disease (AD) is the most common form of dementia. The risk of AD increases
with age. Although two of the main pathological features of AD, amyloid plaques and …
with age. Although two of the main pathological features of AD, amyloid plaques and …
The behavioral, pathological and therapeutic features of the senescence-accelerated mouse prone 8 strain as an Alzheimer's disease animal model
X Cheng, W Zhou, Y Zhang - Ageing Research Reviews, 2014 - Elsevier
Alzheimer's disease (AD) is a widespread and devastating progressive neurodegenerative
disease. Disease-modifying treatments remain beyond reach, and the etiology of the …
disease. Disease-modifying treatments remain beyond reach, and the etiology of the …
The effect of ageing on neurogenesis and oxidative stress in the APPswe/PS1deltaE9 mouse model of Alzheimer's disease
A Hamilton, C Holscher - Brain research, 2012 - Elsevier
Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterised by
memory loss and impaired cognitive function. One of the hallmarks of AD is the formation of …
memory loss and impaired cognitive function. One of the hallmarks of AD is the formation of …
Antimalarial drug Artemisinin extenuates amyloidogenesis and neuroinflammation in APP swe/PS 1dE9 Transgenic Mice via inhibition of nuclear factor‐κ B and NLRP …
JQ Shi, CC Zhang, XL Sun, XX Cheng… - CNS neuroscience & …, 2013 - Wiley Online Library
Background The activation of nuclear factor‐kappa B (NF‐κB) and NLRP 3 inflammasome is
involved in neuroinflammation, which is closely linked to A lzheimer's disease (AD). In vivo …
involved in neuroinflammation, which is closely linked to A lzheimer's disease (AD). In vivo …
[HTML][HTML] Retinal capillary degeneration and blood-retinal barrier disruption in murine models of Alzheimer's disease
Extensive effort has been made studying retinal pathology in Alzheimer's disease (AD) to
improve early noninvasive diagnosis and treatment. Particularly relevant are vascular …
improve early noninvasive diagnosis and treatment. Particularly relevant are vascular …
Antiepileptics topiramate and levetiracetam alleviate behavioral deficits and reduce neuropathology in APP swe/PS 1dE9 transgenic mice
JQ Shi, BR Wang, YY Tian, J Xu, L Gao… - CNS neuroscience & …, 2013 - Wiley Online Library
Background The close relationship between epileptic seizure and Alzheimer's disease (AD)
has been demonstrated in the past decade. Valproic acid, a traditional first‐line antiepileptic …
has been demonstrated in the past decade. Valproic acid, a traditional first‐line antiepileptic …