Despite the recent advances in chemotherapeutic treatments against cancer, some types of
highly aggressive and invasive cancer develop drug resistance against conventional …

Radiotherapy is an important component of anti-cancer treatment. However, not all cancer
patients respond to radiotherapy, and with current knowledge clinicians are unable to …

DNA methylation can regulate gene expression and has been shown to modulate cancer
cell biology and chemotherapy resistance. Therapeutic radiation results in a biological …

In the present study, we investigate the effect of homocysteine (Hcy) on extracellular-
superoxide dismutase (EC-SOD) DNA methylation in the aorta of mice, and explore the …

Tamoxifen (TAM) resistance is a serious clinical problem in the treatment of breast cancer.
Here, we found that S-adenosylmethionine (SAM) and DNA methyltransferase1 (DNMT1) …

Acquired resistance against doxorubicin is a major limitation in clinical treatment of breast
cancer. The molecular mechanism behind the aberrant expression of genes leading to …

An understanding of cellular processes that determine the response to ionizing radiation (IR)
exposure is essential to improve radiotherapy and to assess risks to human health after …

Digits shape is sculpted by interdigital programmed cell death during limb development.
Here, we show that DNA breakage in the periphery of 5-methylcytosine nuclei foci of …

Atherosclerosis (AS) is a disease induced by multiple factors, including genetic and
environmental elements. The aim of the present study is to investigate the comprehensive …

Radiotherapy (RT) is a central treatment modality for breast cancer patients. The purpose of
our study was to investigate the DNA methylation changes in tumors following RT, and to …