Early life stress (ELS) is a known risk factor for suffering psychopathology in adulthood. The
hypothalamic–pituitary–adrenal (HPA) axis has been described to be deregulated in both …

Aside from its selective role in filtering inter‐individual variation during evolution by natural
selection, the environment also plays an instructive role in producing variation during …

Abstract Background Prostate cancer (PCa) has the highest incidence rates of cancers in
men in western countries. Unlike several other types of cancer, PCa has few genetic drivers …

Epigenetic mechanisms control various functions throughout the body, from cell fate
determination in development to immune responses and inflammation. Neuroinflammation …

One of the most significant problems in industrial bioprocessing of recombinant proteins
using engineered mammalian cells is the phenomenon of cell line instability, where a …

Large scale distributed systems like Grids are difficult to study only from theoretical models
and simulators. Most Grids deployed at large scale are production platforms that are …

N6-methyladenosine (m6A) modification has been reported as a critical regulator of gene
transcript expression. Although m6A modification plays important roles in tumor …

Aging is the single most important risk factor for diseases that are currently the leading
causes of morbidity and mortality. However, there is considerable inter-individual variability …

Neo-Darwinian explanations of organic evolution have settled on mutation as the principal
factor in producing evolutionary novelty. Mechanistic characterizations have been also …

Terahertz (THz) radiation can affect the degree of DNA methylation, the spectral
characteristics of which exist in the terahertz region. DNA methylation is an epigenetic …