Cancer epigenetics in clinical practice
V Davalos, M Esteller - CA: a cancer journal for clinicians, 2023 - Wiley Online Library
Cancer development is driven by the accumulation of alterations affecting the structure and
function of the genome. Whereas genetic changes disrupt the DNA sequence, epigenetic …
function of the genome. Whereas genetic changes disrupt the DNA sequence, epigenetic …
[HTML][HTML] Circulating tumor DNA minimal residual disease detection of non–small-cell lung cancer treated with curative intent
B Pellini, AA Chaudhuri - Journal of Clinical Oncology, 2022 - ncbi.nlm.nih.gov
Circulating tumor DNA (ctDNA) minimal residual disease (MRD) is a powerful biomarker
with the potential to improve survival outcomes for non–small-cell lung cancer (NSCLC) …
with the potential to improve survival outcomes for non–small-cell lung cancer (NSCLC) …
Single test-based diagnosis of multiple cancer types using Exosome-SERS-AI for early stage cancers
Early cancer detection has significant clinical value, but there remains no single method that
can comprehensively identify multiple types of early-stage cancer. Here, we report the …
can comprehensively identify multiple types of early-stage cancer. Here, we report the …
Bridging biological cfDNA features and machine learning approaches
T Moser, S Kühberger, I Lazzeri, G Vlachos, E Heitzer - Trends in Genetics, 2023 - cell.com
Liquid biopsies (LBs), particularly using circulating tumor DNA (ctDNA), are expected to
revolutionize precision oncology and blood-based cancer screening. Recent technological …
revolutionize precision oncology and blood-based cancer screening. Recent technological …
Circulating tumor cells in precision medicine: challenges and opportunities
The mutational and phenotypic landscape of tumors is dynamic, requiring constant
monitoring of cancer patients to provide the most up-to-date and effective care. Circulating …
monitoring of cancer patients to provide the most up-to-date and effective care. Circulating …
Cell-free DNA-based liquid biopsies in neurology
This article reviews recent developments in the application of cell-free DNA-based liquid
biopsies to neurological diseases. Over the past few decades, an explosion of interest in the …
biopsies to neurological diseases. Over the past few decades, an explosion of interest in the …
Potential clinical utility of liquid biopsy in early-stage non-small cell lung cancer
H Shen, Y Jin, H Zhao, M Wu, K Zhang, Z Wei, X Wang… - BMC medicine, 2022 - Springer
Background Liquid biopsy has been widely researched for early diagnosis, prognostication
and disease monitoring in lung cancer, but there is a need to investigate its clinical utility for …
and disease monitoring in lung cancer, but there is a need to investigate its clinical utility for …
PHF14 enhances DNA methylation of SMAD7 gene to promote TGF-β-driven lung adenocarcinoma metastasis
H Tian, C Liu, J Yu, J Han, J Du, S Liang, W Wang… - Cell Discovery, 2023 - nature.com
Aberrant activation of TGF-β signaling plays a pivotal role in cancer metastasis and
progression. However, molecular mechanisms underlying the dysregulation of TGF-β …
progression. However, molecular mechanisms underlying the dysregulation of TGF-β …
Liquid biopsy to detect minimal residual disease: methodology and impact
N Honoré, R Galot, C van Marcke, N Limaye… - Cancers, 2021 - mdpi.com
Simple Summary The field of liquid biopsy is rapidly evolving. Techniques that improve
accuracy are constantly being developed, and clinicians increasingly use liquid biopsy as a …
accuracy are constantly being developed, and clinicians increasingly use liquid biopsy as a …
[HTML][HTML] Blood-based DNA methylation signatures in cancer: A systematic review
Y Li, Z Fan, Y Meng, S Liu, H Zhan - … Acta (BBA)-Molecular Basis of Disease, 2023 - Elsevier
DNA methylation profiles are in dynamic equilibrium via the initiation of methylation,
maintenance of methylation and demethylation, which control gene expression and …
maintenance of methylation and demethylation, which control gene expression and …