Thrombotic microangiopathy can manifest in a diverse range of diseases and is
characterized by thrombocytopenia, microangiopathic hemolytic anemia, and organ injury …

The complement system is an essential component of the innate immune system that
participates in elimination of pathogens and altered host cells and comprises an essential …

Genomic sequencing provides many opportunities in newborn clinical care, but the
challenges of interpreting and reporting newborn genomic sequencing (nGS) results need to …

Background The hemolytic–uremic syndrome consists of the triad of microangiopathic
hemolytic anemia, thrombocytopenia, and renal failure. The common form of the syndrome …

Factor H autoantibodies have been reported in approximately 10% of patients with atypical
hemolytic uremic syndrome (aHUS) and are associated with deficiency of factor H–related …

Atypical hemolytic uremic syndrome (aHUS) is a disease of complement dysregulation. In
approximately 50% of patients, mutations have been described in the genes encoding the …

Atypical hemolytic uremic syndrome (aHUS) is associated with defective complement
regulation. Disease-associated mutations have been described in the genes encoding the …

Atypical haemolytic uraemic syndrome (aHUS) is associated with a poor prognosis with
regard to survival at presentation, recovery of renal function and transplantation. It is now …

Hemolytic uremic syndrome (HUS) is a rare disease. In this work the authors review the
recent findings on HUS, considering the different etiologic and pathogenetic classifications …

Complement-mediated thrombotic microangiopathy (CM-TMA) is a clinical disorder driven
by the generation of excess complement. It is characterized by thrombocytopenia and …