[HTML][HTML] Smooth muscle cell-specific Notch1 haploinsufficiency restricts the progression of abdominal aortic aneurysm by modulating CTGF expression

J Sachdeva, A Mahajan, J Cheng, JT Baeten, B Lilly… - PloS one, 2017 - journals.plos.org
Aims Infiltration of macrophages and apoptosis of vascular smooth muscle cells (VSMCs)
promote the development of abdominal aortic aneurysm (AAA). Previously, we …

[HTML][HTML] Histone acetylation and histone acetyltransferases show significant alterations in human abdominal aortic aneurysm

Y Han, F Tanios, C Reeps, J Zhang, K Schwamborn… - Clinical …, 2016 - Springer
Background Epigenetic modifications may play a relevant role in the pathogenesis of human
abdominal aortic aneurysm (AAA). The aim of the study was therefore to investigate histone …

Extra-and intraluminal elastase induce morphologically distinct abdominal aortic aneurysms in mice and thus represent specific subtypes of human disease

A Busch, A Holm, N Wagner, S Ergün… - Journal of vascular …, 2016 - karger.com
Topical application of elastase to induce arterial aneurysm formation is an emerging murine
model of vascular disease. In the context of aortic abdominal aneurysm (AAA), angiotensin II …

Interleukin 12p40 deficiency promotes abdominal aortic aneurysm by activating CCN2/MMP2 pathways

N Sharma, CP Hans - Journal of the American Heart Association, 2021 - Am Heart Assoc
Background Development of abdominal aortic aneurysm (AAA) is associated with
proinflammatory cytokines including interleukin‐12 (IL12). Deficiency of interleukin 12p40 …

Vascular effects of glycoprotein130 ligands—Part II: Biomarkers and therapeutic targets

S Demyanets, K Huber, J Wojta - Vascular Pharmacology, 2012 - Elsevier
Glycoprotein130 (gp130) ligands are defined by the use of the common receptor subunit
gp130 and comprise interleukin (IL)-6, oncostatin M (OSM), IL-11, leukemia inhibitory factor …

[HTML][HTML] Completing the view–histologic insights from circular AAA specimen including 3D imaging: A methodologic approach towards histologic analysis of …

AL Menges, M Nackenhorst, JR Müller, ML Engl… - Diagnostic …, 2023 - Springer
Abdominal aortic aneurysm (AAA) is a pathologic enlargement of the infrarenal aorta with an
associated risk of rupture. However, the responsible mechanisms are only partially …

[HTML][HTML] Circumferential heterogeneity in the abdominal aortic aneurysm wall composition suggests lateral sides to be more rupture prone

R Hurks, G Pasterkamp, A Vink, IE Hoefer… - Journal of vascular …, 2012 - Elsevier
OBJECTIVE: The purpose of this study was to identify local differences in inflammation and
tissue degradation within the circumference of the abdominal aortic aneurysm (AAA) …

[HTML][HTML] Gene expression profiling in abdominal aortic aneurysms

AL Behrens, S Dihlmann, C Grond-Ginsbach… - Journal of Clinical …, 2022 - mdpi.com
Gene expression profiling of abdominal aortic aneurysms (AAA) indicates that chronic
inflammatory responses, active matrix metalloproteinases, and degradation of the …

Pathophysiology of abdominal aortic aneurysms

A Busch, F Simon, C Schrimpf, AL Menges… - Gefäßchirurgie, 2018 - Springer
Zusammenfassung Hintergrund Das abdominale Aortenaneurysma (AAA) ist eine tägliche
klinische Herausforderung für den Gefäßchirurgen. In den letzten Jahren sind viele …

Vascular inflammation in systemic rheumatic diseases

MD Ivana Hollan - Current Medical Literature, 2011 - search.proquest.com
34 Ivana Hollan inflammation [10, 11]. However, the findings from MRI techniques are not
specific for active inflammation, and FDG-PET is not suitable for the detection of lesions< 4 …