Vascular mechanotransduction
This review aims to survey the current state of mechanotransduction in vascular smooth
muscle cells (VSMCs) and endothelial cells (ECs), including their sensing of mechanical …
muscle cells (VSMCs) and endothelial cells (ECs), including their sensing of mechanical …
Polycystic kidney disease
C Bergmann, LM Guay-Woodford, PC Harris… - Nature reviews Disease …, 2018 - nature.com
Cystic kidneys are common causes of end-stage renal disease, both in children and in
adults. Autosomal dominant polycystic kidney disease (ADPKD) and autosomal recessive …
adults. Autosomal dominant polycystic kidney disease (ADPKD) and autosomal recessive …
Renal plasticity revealed through reversal of polycystic kidney disease in mice
Initiation of cyst formation in autosomal dominant polycystic kidney disease (ADPKD) occurs
when kidney tubule cells are rendered null for either PKD1 or PKD2 by somatic 'second …
when kidney tubule cells are rendered null for either PKD1 or PKD2 by somatic 'second …
[HTML][HTML] Modelling kidney disease with CRISPR-mutant kidney organoids derived from human pluripotent epiblast spheroids
BS Freedman, CR Brooks, AQ Lam, H Fu… - Nature …, 2015 - nature.com
Abstract Human-pluripotent-stem-cell-derived kidney cells (hPSC-KCs) have important
potential for disease modelling and regeneration. Whether the hPSC-KCs can reconstitute …
potential for disease modelling and regeneration. Whether the hPSC-KCs can reconstitute …
TRP channels as cellular sensors
DE Clapham - Nature, 2003 - nature.com
TRP channels are the vanguard of our sensory systems, responding to temperature, touch,
pain, osmolarity, pheromones, taste and other stimuli. But their role is much broader than …
pain, osmolarity, pheromones, taste and other stimuli. But their role is much broader than …
Polycystins 1 and 2 mediate mechanosensation in the primary cilium of kidney cells
SM Nauli, FJ Alenghat, Y Luo, E Williams, P Vassilev… - Nature …, 2003 - nature.com
Several proteins implicated in the pathogenesis of polycystic kidney disease (PKD) localize
to cilia. Furthermore, cilia are malformed in mice with PKD with mutations in TgN737Rpw …
to cilia. Furthermore, cilia are malformed in mice with PKD with mutations in TgN737Rpw …
An introduction to TRP channels
IS Ramsey, M Delling, DE Clapham - Annu. Rev. Physiol., 2006 - annualreviews.org
▪ Abstract The aim of this review is to provide a basic framework for understanding the
function of mammalian transient receptor potential (TRP) channels, particularly as they have …
function of mammalian transient receptor potential (TRP) channels, particularly as they have …
[HTML][HTML] Genetic mechanisms and signaling pathways in autosomal dominant polycystic kidney disease
PC Harris, VE Torres - The Journal of clinical investigation, 2014 - Am Soc Clin Investig
Recent advances in defining the genetic mechanisms of disease causation and modification
in autosomal dominant polycystic kidney disease (ADPKD) have helped to explain some …
in autosomal dominant polycystic kidney disease (ADPKD) have helped to explain some …
Transient receptor potential cation channels in disease
The transient receptor potential (TRP) superfamily consists of a large number of cation
channels that are mostly permeable to both monovalent and divalent cations. The 28 …
channels that are mostly permeable to both monovalent and divalent cations. The 28 …
[HTML][HTML] Functional polycystin-1 dosage governs autosomal dominant polycystic kidney disease severity
Autosomal dominant polycystic kidney disease (ADPKD) is caused by mutations to PKD1 or
PKD2, triggering progressive cystogenesis and typically leading to end-stage renal disease …
PKD2, triggering progressive cystogenesis and typically leading to end-stage renal disease …