We herein disclose how global cyclodextrin-based pharmaceutical technologies have
evolved since the early 80s through a 1998 patents dataset retrieved from Derwent …

Absence of safe, effective and appropriate treatment is one of the main causes of high
mortality and morbidity rates among the pediatric group. This review provides an overview of …

The aim of this study was to develop a palatable donepezil (DP) orodispersible film (ODF) to
facilitate the swallowing process and investigate the effect of cyclodextrin on taste-masking …

Undesirable taste is an important problem for patient compliance. Several oral
pharmaceuticals and bulking agents have disagreeable and bitter-tasting components. The …

Benzodiazepines form a class of drugs that are used to treat wide variety of conditions such
as anxiety, seizures, and insomnia. In general, benzodiazepines are lipophilic and poorly …

Epinephrine is a life-saving treatment in anaphylaxis. In community settings, a first-aid dose
of epinephrine is injected from an auto-injector (EAI). Needle phobia highly contributes to …

We investigated the ionization profiles for open-ring (OR) and closed-ring (CR) forms of
midazolam and drug-binding modes with heptakis-(2, 3, 6-tri-O-methyl)-β-cyclodextrin …

Cyclodextrins (CDs) are cyclic oligosaccharides obtained from starch. They present a
hydrophobic outer and a hydrophobic cavity and they can complex hydrophobic molecules …

Midazolam (MDZ) is a benzodiazepine commonly administered in preanesthesia of children
by oral or by sublingual routes. To mask its bitter taste and enhance its aqueous solubility …

Midazolam (MDZ) is a short acting benzodiazepine not only used in treatment of pediatric
status epilepticus but also is the most common preoperative sedative-agent in many surgical …