The aminoglycosides are broad-spectrum, bactericidal antibiotics that are commonly
prescribed for children, primarily for infections caused by Gram-negative pathogens. The …

Background To document covariates which contribute to inter-individual variability in
propofol pharmacokinetics in preterm and term neonates. Methods Population …

Neonatal cancer is rare and comprises a heterogeneous group of neoplasms with
substantial histological diversity. Almost all types of paediatric cancer can occur in fetuses …

Completely revised and updated, Developmental and Reproductive Toxicology: A Practical
Approach, Second Edition draws together valuable information typically scattered …

The occurrence of hypersensitivity reactions including rare but life‐threatening Stevens–
Johnson syndrome (SJS) and drug‐induced hypersensitivity syndrome (HSS) limits the use …

Background The evidence from individual studies to support the maturational pattern of GFR
in healthy, term-born neonates is inconclusive. We performed an individual participant data …

Many critically ill patients display a supraphysiological renal function with enhanced renal
perfusion and glomerular hyperfiltration. This phenomenon described as augmented renal …

Pharmacokinetic/pharmacodynamic (PKPD) modeling is important in the design and
conduct of clinical pharmacology research in children. During drug development, PKPD …

There are more than 40 H1‐antihistamines available worldwide. Most of these medications
have never been optimally studied in prospective, randomized, double‐masked, placebo …

ABSTRACT The World Health Organization (WHO) recently issued revised first-line
antituberculosis (anti-TB) drug dosage recommendations for children. No pharmacokinetic …