Cryptococcus neoformans (C. neoformans) is a pathogenic fungus with a global distribution.
Humans become infected by inhaling the fungus from the environment, and the fungus …

The respiratory tree maintains sterilizing immunity against human fungal pathogens.
Humans inhale ubiquitous filamentous molds and geographically restricted dimorphic fungal …

The outcome of cryptococcal pneumonia correlates with local macrophage polarization
status, as M1 and M2 polarization marks protective and nonprotective responses …

The role and origin of alveolar macrophages (AMs) in asthma are incompletely defined. We
sought to clarify these issues in the context of acute allergic lung inflammation using house …

The lungs are constantly exposed to environmental and infectious agents such as dust,
viruses, fungi, and bacteria that invade the lungs upon breathing. The lungs are equipped …

We describe a human lung disease caused by autosomal recessive, complete deficiency of
the monocyte chemokine receptor CC motif chemokine receptor 2 (CCR2). Nine children …

Cryptococcus species are environmental fungal pathogens and the causative agents of
cryptococcosis. Infection occurs upon inhalation of infectious particles, which proliferate in …

The alveolar epithelium is characteristically abnormal in fibrotic lung disease, and we
recently established a direct link between injury to the type II alveolar epithelial cell (AEC) …

The fungal pathogen Cryptococcus neoformans can cause life-threatening infections in
immune compromised individuals. This pathogen is typically acquired via inhalation, and …

Cryptococcus neoformans is a leading cause of invasive fungal infections among
immunocompromised patients. However, the cellular constituents of the innate immune …