Variations in phenotype reflect the influence of environmental conditions during
development on cellular functions, including that of the genome. The recent integration of …

In the present article the putative role of environmental factors in schizophrenia is reviewed
and synthesized. Accumulating evidence from recent studies suggests that environmental …

The promise of targeting epigenetic abnormalities for cancer therapy has not been realized
for solid tumours, although increasing evidence is demonstrating its worth in haematological …

Corneal endothelium is the single layer of cells forming a boundary between the corneal
stroma and anterior chamber. The barrier and “pump” functions of the endothelium are …

There are numerous examples in psychology and other disciplines of the enduring effects of
early experience on neural function. In this article, we review the emerging evidence for …

Germ cells have the unique capacity to start a new life upon fertilization. They are generated
during a sex-specific differentiation programme called gametogenesis. Maturation of germ …

Endocrine disruptors have recently been shown to promote an epigenetic transgenerational
phenotype involving a number of disease states (eg male infertility). The anti-androgenic …

The findings from investigations of the neuroendocrinology of posttraumatic stress disorder
(PTSD) have highlighted alterations that have not historically been associated with …

Normal cells have limited proliferative potential in culture, a fact that has been the basis of
their use as a model for replicative senescence for many years. Recent molecular analyses …

In two interrelated articles, the current revision of the functional matrix hypothesis extends to
a reconsideration of the relative roles of genomic and of epigenetic processes and …