In this review, we comprehensively present the function of epigenetic regulations in normal
placental development as well as in a prominent disease of placental origin, preeclampsia …

BACKGROUND The placenta is the active interface between mother and foetus, bearing the
molecular marks of rapid development and exposures in utero. The placenta is routinely …

Objective Parental environmental exposures can strongly influence descendant risks for
adult disease. How paternal obesity changes the sperm chromatin leading to the acquisition …

Background Preeclampsia is a life-threatening disorder of pregnancy, demonstrating a high
degree of heterogeneity in clinical features such as presentation, disease severity, and …

Background A normally developed placenta is integral to a successful pregnancy.
Preeclampsia (PE) and intrauterine growth restriction (IUGR) are two common pregnancy …

Preeclampsia is a medical condition affecting 5–10% of pregnancies. It has serious effects
on the health of the pregnant mother and developing fetus. While possible causes of …

Although male–female differences in placental structure and function have been observed,
little is understood about their molecular underpinnings. Here, we present a mega-analysis …

Preeclampsia affects about 3–8% of all pregnancies. It represents a complex and
multifaceted syndrome with at least several potential pathways leading to the development …

Preeclampsia is a multisystemic pregnancy disorder and a major cause of maternal and
neonatal morbidity and mortality worldwide. The exact pathophysiology of preeclampsia …

The placenta is the interface between maternal and fetal circulations, integrating maternal
and fetal signals to selectively regulate nutrient, gas, and waste exchange, as well as …