Bladder cancer is a highly prevalent disease and is associated with substantial morbidity,
mortality and cost. Environmental or occupational exposures to carcinogens, especially …

Urothelial carcinoma of the bladder comprises two long-recognized disease entities with
distinct molecular features and clinical outcome. Low-grade non-muscle-invasive tumours …

The ability of circulating tumor cells (CTCs) to form clusters has been linked to increased
metastatic potential. Yet biological features and vulnerabilities of CTC clusters remain …

We report a comprehensive analysis of 412 muscle-invasive bladder cancers characterized
by multiple TCGA analytical platforms. Fifty-eight genes were significantly mutated, and the …

Urine markers to detect bladder cancer have been the subject of research for decades. The
idea that urine—being in continuous contact with tumour tissue—should provide a vector of …

Cancer cells typically exhibit aberrant DNA methylation patterns that can drive malignant
transformation. Whether cancer cells are dependent on these abnormal epigenetic …

Urinary bladder cancer is the fifth most common cancer in the Western world. Increasing
evidence has shown that DNA methylation in bladder cancer is expansive and is implicated …

Abstract Purpose of Review Bladder cancer (BC) is the second most common genitourinary
malignancy, with a growing population of survivors globally. Over the past two decades …

Despite the fact that 45% of all human gene promoters do not contain CpG islands, the role
of DNA methylation in control of non-CpG island promoters is controversial and its relevance …

Purpose: Epigenetic alterations are common and can now be addressed in a parallel
fashion. We investigated the methylation in bladder cancer with respect to location in …