Primary cilia are solitary, immotile sensory organelles present on most cells in the body that
participate broadly in human health, physiology and disease. Cilia generate a unique …

Polycystin subunits can form hetero-and homotetrameric ion channels in the membranes of
various compartments of the cell. Homotetrameric polycystin channels are voltage-and …

Autosomal dominant polycystic kidney disease (ADPKD), characterized by progressive cyst
formation/expansion, results in enlarged kidneys and often end stage kidney disease …

Primary cilia are small, antenna-like organelles that detect and transduce chemical and
mechanical cues in the extracellular environment, regulating cell behavior and, in turn …

Ciliary extracellular vesicle (EV) shedding is evolutionarily conserved. In Chlamydomonas
and C. elegans, ciliary EVs act as signaling devices. 1–3 In cultured mammalian cells, ciliary …

The past 40 years in Southeast Asia have seen about 50% of lowland rainforests converted
to oil palm and other plantations, and much of the remaining forest heavily logged. Little is …

Primary cilia project from the surface of most vertebrate cells and are key in sensing
extracellular signals and locally transducing this information into a cellular response. Recent …

Primary cilia act as cell surface antennae, coordinating cellular responses to sensory inputs
and signalling molecules that regulate developmental and homeostatic pathways. Cilia are …

Polycystic kidney disease (PKD), comprising autosomal dominant polycystic kidney disease
(ADPKD) and autosomal recessive polycystic kidney d isease (ARPKD), is characterized by …

The initial breaking of left-right (L–R) symmetry in the embryo is controlled by a motile-cilia-
driven leftward fluid flow in the left-right organiser (LRO), resulting in L–R asymmetric gene …